Articles, Blog

Your Brain On Coffee

August 20, 2019

With it’s stimulating effects, it’s easy
to understand why coffee is the second most traded commodity on Earth after oil. For many,
it keeps us awake and moving through our busy days. But how does it work? What exactly does
coffee do to your brain? Whenever you’re awake, a chemical called
adenosine slowly accumulates in your brain. And this adenosine binds to receptors which
slow down brain activity – ultimately, the more adenosine there is, the more tired your
brain feels. Which makes sense, as the longer you’re awake, the more fatigued you become.
Conversely, while you sleep, the concentration of adenosine declines, gradually promoting
wakefulness. But it turns out that the caffeine in your
coffee is incredibly similar to adenosine in structure. The caffeine works it’s way
through your bloodstream and into the brain, where it starts to compete and binds with
adenosine receptors. But because it’s not adenosine, the ‘sleepiness’ effect isn’t
felt. Adenosine can no longer bind, meaning it’s calming properties are diminished.
Which is great for you when you’re feeling tired! However, with long term use of caffeine,
your brain responds by creating more adenosine receptors – which means more caffeine is required
to elicit the same response. It also means that when you try to quit drinking coffee
or miss your daily intake, you might experience some withdrawal symptoms and feel more tired
than you would have before you ever drank coffee! But the caffeine doesn’t stop there! It
also stimulates the production of adrenaline – you know, the Fight or Flight hormone? This
increases your heart rate, gets your blood pumping, and even opens up your airways. Furthermore,
it affects Dopamine levels by preventing its reabsorption in the brain, which makes you
feel happy! In fact, this is the exact same thing that cocaine does, just to a lesser
degree. It’s a drug, afterall! This dopamine stimulation is also the aspect of coffee that
makes it moderately addictive. So can you drink too much coffee? It turns
out there is a lethal dose of caffeine which is somewhere around 150mg of caffeine per
kilogram of your body. This means if you weigh 70kg you would require 14,000mg of caffeine
to overdose. Put into perspective, an average cup of coffee contains roughly 150mg of caffeine,
meaning if you are 70kg, approximately 70 cups of coffee would kill you. However, you’d
have to drink those cups all at once making it effectively impossible to overdose on caffeine
from coffee, since you wouldn’t be able to physically fit that much in your stomach.
You’d also start experiencing mania and hallucinations before getting to this point. Caffeine also has a halflife of around 6 hours
-so if you drank a standard coffee with around 150mg of caffeine, after about 6 hours there
will only be 75mg left in your system and you’ll be feeling half of the effect. And
6 hours after that, you’ll have 37.5mg – leaving more room for adenosine to jump back into
action. Which is why you may reach for another cup throughout the day, to maintain that glorious,
alert and energetic feeling. So drink up! And enjoy the buzz…while it
lasts 🙂 And for all of you in school, while we know
caffeine is key, so are good deals on textbooks! So we’ve teamed up with to
get you the cheapest prices for the books you need. All you have to do is head to
and search the ISBN number of the books your looking for. SlugBooks will then compare prices
from all across the net. Seriously, we know how expensive textbooks can be, so hopefully
this will save you some money! Special thanks to SlugBooks for supporting AsapSCIENCE. Got a burning question you want answered? Ask it in the comments or on Facebook or Twitter. And subscribe for more weekly science videos!


  • Reply Rodrigo Ruiz March 4, 2019 at 6:21 pm

    Coffee makes me sleepy

  • Reply h. ann March 4, 2019 at 6:48 pm

    I've seen kids in my city overdose on caffeine pills, most of them students.

  • Reply VolcanoBeast March 6, 2019 at 1:07 pm

    More like your brain on TikTok…..

  • Reply KanzakiZero March 10, 2019 at 3:24 pm

    I drank 2 cups of coffee and my head feels really weird for some reason

  • Reply dejan kuzmanovic March 13, 2019 at 10:34 am

    More like your coffee on brain

  • Reply Daniel Luster March 15, 2019 at 11:23 pm

    I wish that I could have some caffeinated coffee. 🙁

  • Reply bro it's just me March 18, 2019 at 12:05 am

    What about tea ?

  • Reply Caterina Christakos March 18, 2019 at 9:08 pm

    Really video. I have used the 7 figure franchise and have really earned commissions. Click here to view my testimonial}:

  • Reply LittleMonsterIsMyName March 20, 2019 at 3:08 pm

    I drink coffee so i wouldn't have headaches from my low blood pressure

  • Reply wha wha March 22, 2019 at 12:56 pm

    coffee gives me ADHD

  • Reply Emma March 23, 2019 at 1:07 pm

    Im watching while drinking super – strong coffee ☕😝

  • Reply oneAfter9 traXX March 27, 2019 at 4:39 pm

    Hello! Can you make a video about pulling an all nighter? Thank u 😀

  • Reply Jennifer vogt March 30, 2019 at 6:20 am

    I’m a crackhead for coffee

  • Reply Kayann Henry April 4, 2019 at 9:59 pm

    How many shots of espresso until I start hallucinating?.. is the real question.

  • Reply Joel Toivonen April 6, 2019 at 8:46 am

    I'm drinking coffee while watching this☕

  • Reply rudeboymon April 7, 2019 at 8:07 am

    Caffeine makes me periodically psychotic

  • Reply G S April 7, 2019 at 1:40 pm

    Remember people, it's ok to DRINK your drugs.

  • Reply Flat adam April 8, 2019 at 5:20 am

    Is it possible to become immune to coffee

    Because i chug it and it does nothing to keep me awake

    I just wanna get my work doneeee

  • Reply Tesalonika Gabrielle April 8, 2019 at 8:09 am

    i drink coffee and i dont feel any effects.. but who knows what actually happened in my body lmao

  • Reply Archana Archana April 10, 2019 at 8:19 am

    Ok so im addicted to coffee.

  • Reply Caterina Christakos April 12, 2019 at 9:06 pm

    very video. I am a franchisee of the 7 figure franchise by Michael Cheney and have really had $1000 days. Click here to see my testimonial}:

  • Reply S.A.D. April 13, 2019 at 5:31 am

    You guys should make one about Kratom.

  • Reply Theangry Italian April 13, 2019 at 4:42 pm

    At 1:50 surely it should be 150 X 70 = 10500. The video says that it equals 14000

  • Reply ERROR 404 NOT FOUND April 15, 2019 at 2:38 pm

    I drink coffee every morning at 6:00 AM and I feel like I slept 11 hours and only slept like 5-6 hours

  • Reply freya disrud April 16, 2019 at 10:15 pm

    I’m allergic to coffee and I drank it two hours ago. I feel super weird. My brain feels weird

  • Reply Quick Maths April 17, 2019 at 5:44 am

    I still don’t drink coffe

  • Reply vegan April 18, 2019 at 8:02 pm

    in soviet russia, coffee is on your brain

  • Reply Ray Yuen April 19, 2019 at 6:50 am

    I'm a coffee addict and was awarded a gold medal in coffee drinking championship. 😚

  • Reply Rewnyx 95 April 19, 2019 at 11:02 am

    Cofain i sniff it up

  • Reply Miguel Nogueira April 21, 2019 at 6:45 pm

    2:52 I totally misunderstood that as SlutBooks lmao

  • Reply Chase Prairie April 21, 2019 at 9:31 pm

    I'm not sure how you did your math, but 150 mg/kg times 70 kg is 10,500 mg – your 14,000 mg calculation is off.

  • Reply Last Firstxxa April 23, 2019 at 1:51 am

    I like coffee but I’m not addicted to it

  • Reply SuperSaiyan Zero April 24, 2019 at 4:13 pm

    Columbian decaf coffee crystals.

  • Reply snipez _r1 April 27, 2019 at 4:47 pm

    I like coffee sometimes. Taste is good and i like tea sometimes too. But i never really get 'addicted' to it

  • Reply 04dram04 April 30, 2019 at 11:37 pm

    Caffee has really messed me up. I am tired all the time, no matter how much I take. I wish I can stop

  • Reply bjgamer86 May 1, 2019 at 10:45 pm

    I am 10 year old and i drink coffee

  • Reply subaru fan May 1, 2019 at 11:28 pm

    Coffee is starting to make my pupils dialate…idk if thats normal…lol

  • Reply Alqahtani May 2, 2019 at 7:01 am

    ليتهم ما تفلسفوا وترجموا 🌚 كلام بنقالي

  • Reply Andrew May 3, 2019 at 8:34 am

    My suicidal dumbass just heard, "it would take 14000 mg to overdose".

  • Reply Channel Channel May 3, 2019 at 12:27 pm

    Caffeine addiction is a thing, trust me

  • Reply Joshou May 3, 2019 at 3:12 pm

    Coffee makes me hyper and it feels absolutely amazing.

  • Reply rated r May 7, 2019 at 4:07 am

    Nice info bro…thanks

  • Reply Caterina Christakos May 7, 2019 at 9:13 pm

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  • Reply Riddler May 13, 2019 at 12:51 am

    well I had some idea few days ago,I was not a coffee drinker,I drank maybe 5 coffees in my life,but since I was a child I experience hard times to fall asleep,so I thought to myself,maybe I can start drinking coffee and maybe this somehow makes me more sleepy at evening,so in the night I can fall asleep better,well this video somehow confirm this theory is it follows:
    I can grow my adenosine receptors by drinking 1-2 coups of coffee per day,so my adenosine receptors starts to multiplicate,and after that I can fall asleep easier in the night by having more adenosine receptors where adenosine molecules can bind,am I right?

  • Reply Cleo2467 May 15, 2019 at 10:48 pm

    Coffee had no effect on me ever since the first time I tried it. But then you move on to bigger stuff that doesn't have that simple 150 mg, it has just about 750. Then you start feeling stuff, and then you get worried, because now 70 cups at once just wont kill. 10 in one day will, and isn't that interesting.

  • Reply Makhi Crayton May 18, 2019 at 2:18 pm


  • Reply A Bone to Pick May 19, 2019 at 1:40 am

    False. Overdosing is using the amount of a drug at which adverse health affects appear. Overdosing happens long before lethal dose.

  • Reply Fear3Cool May 25, 2019 at 3:36 pm

    The only good video I can find about coffee ☕️ Btw I love coffee 🧒🏻 ❤️ ☕️

  • Reply miikayla May 25, 2019 at 7:07 pm

    i drink coffee with almond milk and i drink coffee like once a week so i guess i’m fine?…idk

  • Reply maruxa cabaleiro saco May 27, 2019 at 8:09 pm

    I drink coffee in the mornig , afternoon and after dinner , even ,when I am too tired to sleep , I just have a cup of milk and coffee , and I sleep faster . I suppose I am a bit of an addict .

  • Reply Spawn of Hermes May 28, 2019 at 9:42 pm

    I drink 3 or 4 cups a day and I keep seeing things move slightly like I'm skitzo

  • Reply DMT elf Ireland May 31, 2019 at 9:49 am

    I like to call it gogo juice or brown water

  • Reply jpix96 June 5, 2019 at 4:49 pm

    hmmm if drinking much caffeine has the response of making more adenosine receptors do they also go away if you stop drinking caffeine?

  • Reply Sogol Heydari June 9, 2019 at 9:29 pm

    how should we stop eating coffe ? 🙁 I can Not control myself😭 I am eating more than the day before 🙁

  • Reply Arsinyx June 11, 2019 at 11:03 pm

    My mom is kinda fidgety now

  • Reply H.Sperer June 12, 2019 at 12:38 am

    2:11 xD

  • Reply why so serious ? June 12, 2019 at 5:51 am

    I Love Coffee!!

  • Reply SrmthfgRockLee June 12, 2019 at 11:03 am

    "long term use=creates more receptors"!ha.!! thats why i dont drink coffee

  • Reply Samit Tuladhar June 14, 2019 at 10:06 am

    Anybody else watching this while sipping coffee? :v

  • Reply BloxyGigi June 14, 2019 at 10:37 am

    is it me or does coffee make absolutely no difference on me?

  • Reply Heulwen Rhosyn June 17, 2019 at 12:17 am

    "Slut books .com" 😂😂😋

  • Reply Sarah Abbott June 17, 2019 at 8:30 pm

    I had a full on panic attack earlier because I consumed 100g choc coffee beans and felt weird. I thought I overdosed and was one of my triggers for summer time depression.
    I’m okay now… I forgot about the caffeine in the beans. Scary to say the least

  • Reply Deceased Fatality June 19, 2019 at 6:41 am

    Coffee doesn’t make me feel anything

  • Reply Niko Bellico June 19, 2019 at 3:14 pm

    I remember going to a friends house one night after work, and his brother and I were really into coke heavy at the time and I had drank the large cans of redbull before going into work, I made the mistake of doing about a gram and a half with them and we stayed up all night playing super smash bros melee till 5 a.m. and I was pacing back and forth around his living room because it felt like my heart was about to come out of my asshole. Needless to say I never touched a redbull again

  • Reply Vicente Dagnino June 21, 2019 at 6:09 am

    Shit just makes a nigga sleepy oh who am I kidding I just want some weed 😥😥

  • Reply spill tea June 24, 2019 at 12:37 am

    The real question is: 1:37 is that cocain real?!

  • Reply BrainPower June 24, 2019 at 12:35 pm

    just do a caffeine fast for One week and everything goes back to normal , i do this every month so i can experience the full benefits with 1-2 cups

  • Reply /* June 24, 2019 at 9:21 pm

    This is why I don't drink coffee

  • Reply NoMouthPlayz Game June 24, 2019 at 9:42 pm

    That is why i cannot sleep

  • Reply Darth Vader June 27, 2019 at 3:08 pm

    So if I drink too much coffee I will be the next Einstein?

  • Reply hannahkate_x June 29, 2019 at 3:08 pm

    I’m scared for doing something like I’ve got a job (work experience) I have to do for a week, I’m scared of talking one on one with my worker, so if I drink coffee in the morning would it help me to Carm down or make me not scared to talk?

  • Reply Good Bye July 4, 2019 at 2:18 am

    Who else watched this because they just woke up from a major caffeine crash

  • Reply Weitter Kadenokouji July 6, 2019 at 1:32 pm

    I can drink plain coffee and I will still sleep like a baby. I wish coffee made me awake like the others

  • Reply Andrew Kemp July 6, 2019 at 7:55 pm

    Coffee makes me jittery but tired at the same time

  • Reply conceal3d July 7, 2019 at 10:53 am

    ai interesting thanks brother

  • Reply Jay Lynn July 9, 2019 at 7:08 pm

    Watching this while on about 6-10 espresso 🤷‍♀️🥰😍💞

  • Reply Old memes Are great July 11, 2019 at 10:15 am

    Is it bad that I just have a small craving for coffee after a year of drinking it?

  • Reply Isaac Rivera July 11, 2019 at 11:13 am

    I love coffee ☕️

  • Reply oliverrando July 12, 2019 at 3:24 am

    Man I love coffee

  • Reply Leo Yang July 13, 2019 at 5:19 pm

    How does coffee give you headaches if you drink too much?

  • Reply sunshinesam July 17, 2019 at 4:38 pm

    coffee makes me sleepy

  • Reply Dr. Love July 23, 2019 at 10:40 pm

    Legal drug!

  • Reply KaoticFear #Kaotic July 24, 2019 at 1:08 am

    I feel nothing when I drink coffee I have to drink energy drinks

  • Reply COK Til You Drop July 24, 2019 at 5:44 am

    I swear I thought he said slut books

  • Reply Israel andersonHOME July 24, 2019 at 10:16 pm

    A few years back, I would always drink caffeinated soda, and I was really feeling the effects. One effect that overwhelmed all was anxiety. I constantly felt anxious. I decided enough is enough, and I went cold turkey. I cheated here and there, but eventually I quit. It is amazing how much better I feel now.

  • Reply Rico loop July 26, 2019 at 12:35 pm

    It is only one legal drug that i can take..

  • Reply Jennifer Corbett July 26, 2019 at 6:57 pm

    This video: Your Brain On Coffee
    Tweek from South Park: THE EXPERT

  • Reply Gene Lariv July 29, 2019 at 6:55 pm

    caffeine. no positives. depression. anxiety. insomnia.

  • Reply ImAndrew 766 July 30, 2019 at 5:28 am

    I drank my first coffee today oh there's one problem im 12 anddd idk if it's good for me should i stop?

  • Reply JoyCon Boyz Forever August 2, 2019 at 4:09 am

    I feel nothing…

  • Reply Lithuaniaball August 3, 2019 at 9:54 pm

    I am coffee addict

  • Reply markmeson August 5, 2019 at 3:20 pm

    Any evidence that adenosine receptors normalize after quitting? How long?

  • Reply Nash John August 9, 2019 at 2:20 am

    Sheldon Cooper brought me here

  • Reply Görkem Türkay August 9, 2019 at 2:50 pm

    may i consume coffee by snorting? does it affect in the same way? probably faster

  • Reply BENJAMIN PEREDA ZAVALA August 12, 2019 at 6:43 pm

    How often can i drink coffee to not build resistance

  • Reply Anything_goes Anything_happens August 12, 2019 at 8:00 pm

    Man I really have a bad caffeine addiction.

  • Reply Wwe Fans August 13, 2019 at 4:09 pm

    Loose stools after drinking coffee

  • Reply Brendan J.T. August 13, 2019 at 8:37 pm

    I experimented one energy drink a day before workouts during a week… which eventually brought me here.

  • Reply F-22 Raptor August 20, 2019 at 10:20 am

    Coffee has no effect on me and I drink it rarely.

  • Reply mazermajestic August 20, 2019 at 2:08 pm

    It's natural that means there are no chemicals lol

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