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Skin Cancer: How a virus might protect against skin cancer.

February 28, 2020

In this video you are going to know about how virus might protect against skin cancer previously Scientists have linked the presence of human papilloma virus to an increased risk of certain cancers In a surprising twist, the latest research finds that the virus might help defend against skin cancer There are more than 100 trusted source strains of human papillomavirus HPV Only a handful of which experts consider to be a risk to human health Scientists have linked these strains with an increased risk of certain cancers, including those of the cervix vulva penis and anus of The remaining strains of HPV many are little more than harmless stowaways on our skin These so-called commensal viruses are the subject of scrutiny for a group of researchers at Massachusetts General Hospital in Boston The scientists recently published a paper in Nature trusted source Which concludes that immunity to these HPV strains may protect against skin cancer? Now you must understand the role of HPV in skin cancer The authors of the recent study were particularly interested in cutaneous squamous cell carcinoma SCC Stating that it is the second most common type of cancer Ultraviolet UV light from the Sun as the primary preventable cause of skin cancer But from 1992 to 2012 the incidence of skin cancer in the United States doubled Scientists are trying to uncover additional ways of lowering the risk of skin cancer Some scientists have theorized that HPV plays a role in SCC This idea is based on earlier research showing that a genus of HPV called beta HPV is present in the majority of skin cancers among people who have received an organ transplant? Individuals belonging to this population have a weakened immune system and are therefore More susceptible to cancers that are linked to viral infections To date though scientists have not identified how beta HPV might increase skin cancer risk The authors of the most recent study wanted to investigate the role of beta HPV in more detail To do this they used both animal models and human tissue What the scientists found turned the theory of beta HPD’s role in skin cancer on its head Let’s understand the relation between HPV immunity and cancer Researchers found that the body’s immune response to beta HPV is key In their experiments mice that demonstrated an immune response to HPV seemed to have protection from the development of SCC following carcinogenic UV or chemical exposure Similarly when the researchers transplanted t-cells from those mice into immunocompromised Mice the recipients also developed protection against skin cancer In short it is not beta HPV that encourages SCC in immunocompromised individuals Instead it is the loss of immune function that increases the risk of SCC According to lead author, dr Shonda Mary This is the first evidence that commensal viruses could have beneficial health effects both in Experimental models and also in humans looking to the future These findings open interesting new avenues that might lead to new ways of reducing the risk of SCC The authors write T cell based vaccines against commensal HB vs May provide an innovative approach to boost this antiviral immunity in the skin and help prevent warts and skin cancers in high-risk populations To treat skin cancer doctors sometimes use a type of immunotherapy called immune checkpoint blockade therapy The authors also hope that increasing anti HPV immunity may improve the efficacy of this type of treatment Currently gut bacteria and the microbiome at large are receiving a great deal of attention However research into the viral the sum of all the viruses living on or in our bodies is also beginning to heat up As some viruses attack bacteria thereby influencing Bacterial populations the complex interplay between the two will be difficult to unfurl Researchers investigating the role of viruses in human disease and Particularly in cancer trusted source are likely to publish an increasing number of studies over the coming years. I Hope you had enjoyed this session and getting the value for your time spend We are excited to have some suggestions from you and willing to see you again in our next video with a promise to bring more useful content Don’t forget to subscribe to our channel if not yet subscribed and get the regular updates for future videos Thanks for your time and wish you a healthy and wealthy life You

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