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Q & A: Could oral candidal infections (hyperplastic candidiasis) cause dysplasia?

August 16, 2019


Candidal infections could sometimes
induce a hyperplastic tissue response manifesting as a white lesion that
cannot be rubbed off. Such lesions are termed hyperplastic candidiasis and are
also called Candidal leukoplakia or Candida associated leukoplakia. Some
researchers doubt whether this condition could arise as a result of Candida and
believe it to be a candidal infection superimposed on an already existing
leukoplakic lesion. However, there are reports that state candidal organisms
could induce hyperplasia and cause hyperkeratotic white lesions. Hyperplastic candidiasis commonly occurs on the retro commercial areas and less often on the
tongue and lips. They are raised, plaque like white lesions which may be homogeneous
or speckled. A biopsy of the lesion is important as apart from being hyper
plastic, it could also show varying degrees of dysplasia. It is reported to have a higher risk of malignant transformation than
conventional leukoplakias. Research shows a positive association of Candida with dysplasia and also reports certain strains of Candida albicans could induce
neoplastic transformation. Although clouded in controversy, some
pathologists and investigators believe hyperplastic candidiasis could cause
dysplastic leukoplakic lesions and regard them as being potentially
malignant

1 Comment

  • Reply John Leaf March 18, 2018 at 7:16 pm

    i have this what the best tretament?

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