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Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment

December 13, 2019


Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment Immediately after virus injection at the tumor site, infection of tumor cells occurs via specific virus entry receptors. This is followed by coordinated transcription of viral genes, including those necessary for viral replication and granulocyte-macrophage colony-stimulating factor (GM-CSF), which leads to production of viruses, cell lysis, and spread of infection within the tumo,r and recruitment of immune cells, including dendritic cells, followed by presentation of tumor antigens from lysed tumor cells as well as viral antigens. This leads to a robust T-cell-mediated antitumor and antiviral response which will clear the OV and, if it is effective, it will also lead to sustained systemic antitumor immunity. This approach has the promise of eliminating not only the infected tumor but also secondary tumors that may result from metastatic growth, as long as they are also recognized by cytotoxic T-cells that recognize tumor-specific antigens at the site of injection.

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