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Millions taking common heartburn drugs are at risk of nasty stomach flu, docs warn – Live News 24

November 30, 2019

MILLIONS of people who take common heartburn drugs could be at risk of a nasty stomach flu, experts have warned  People who took acid-relieving medications, such as Nexium, were 80 per cent more likely to get acute gastroenteritis, researchers found  For a long time these over-the-counter meds, known as proton pump inhibitors (PPIs), were considered to be safe, but new research has suggested concerning side-effects  Dr Mina Tadrous, a scientist at Women’s College Hospital (WCH) in Toronto, said: “Very few people need to be on PPIs long term, but people do end up on them chronically  “And now we’re finding that the drugs are not as safe as we thought. They interact with a bunch of drugs There are some nutritional concerns.  “There’s an increased risk of fracture and an increased risk of infection ” High risk  The new study, published in JAMA Network Open, analysed more than 233,000 people taking PPIs continuously and compared them with nearly 627,000 adults who weren’t taking the drug  When they looked at the 2015-16 winter virus season, they noted that people who took PPIs, including Nexium, Prevacid, Protonix and Prilosec, all the time were 80 per cent more likely to get stomach flu  The researchers, led by Ana-Maria Vilcu of Sorbonne University in Paris, said that because heartburn drugs work to reduce acid, it might increase the risk of infection as stomach acid plays a role in keeping viruses at bay  Dr Tadrous, who provided editorial as part of the study, said: “If you reduce acids, you change the intestinal flora [the beneficial bacteria in the gut known as the microbiome], making you more susceptible to infections ” Study concerns  But experts have raised concerns about the validity of the study and say the findings aren’t conclusive  Dr Arun Swaminath, director of inflammatory bowel disease program, at Lenox Hill Hospital, in New York City, pointed out that the researchers diagnosed someone as having acute gastroenteritis if they received a prescription for medications used to treat it  However, those medications can be used to treat other issues as well. What causes heartburn?  Heartburn is a burning feeling in the chest caused by stomach acid travelling up towards the throat (acid reflux) If it keeps happening, it’s called gastro-oesophageal reflux disease (GORD).  Lots of people get heartburn from time to time There’s often no obvious reason why.  Sometimes it’s caused or made worse by: certain food and drink – such as coffee, alcohol, chocolate, and fatty or spicy foods being overweight smoking pregnancy stress and anxiety some medicines, such as anti-inflammatory painkillers (like ibuprofen) a hiatus hernia – when part of your stomach moves up into your chest  You can ease symptoms by eating smaller, more frequent meals or tryibg to lose excess weight  Another lifestyle change includes raising one end of your bed 10-20cm so your chest and head are above the level of your waist, so stomach acid doesn’t travel up towards your throat  Source: NHS  Another concern he raised is that the study only considered people to be on PPIs continuously if they had a prescription for a PPI  He added: “PPIs are available over the counter in France.  “Assuming all patients who didn’t have a prescription for these medications weren’t exposed to PPI can make the magnitude of the association larger than it really it is ”  Dr Tadrous added that people should consider discontinuing PPI therapy if it’s not clearly necessary and consider dietary changes instead  These include changing the types of food you eat, when you eat and how much you eat  Those who likely need long-term PPI therapy include people who need to take nonsteroidal anti-inflammatory drugs long-term to help prevent ulcers  Also, people with conditions such as severe oesophagitis, Barrett oesophagus, idiopathic chronic ulcer, difficult-to-control gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and some people with bleeding ulcers

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