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Human Disease & Fungal Homologs in SGD’s YeastMine

August 16, 2019

We have recently added OMIM data into YeastMine, an advanced search resource at SGD. You can find homology relationships between yeast genes and human genes and diseases. In addition, fungal homolog information from 24 additional species have been added to YeastMine. Links to YeastMine are found on almost all SGD pages in the upper right corner. From the YeastMine homepage, click on the new tab “HOMOLOGY” to find four new predefined queries, or templates, that allow you to search for the newly added OMIM and fungal data. The first template, “Yeast gene to OMIM human homologs to OMIM disease phenotypes”, allows you to retrieve the human homologs of a given yeast gene, or a list of genes, and any associated disease phenotypes. For instance, searching for the human homologs of PMT3 brings back two different Homo sapiens genes. In the results table, you will find their symbols, names, NCBI identifiers, and the corresponding OMIM entry and any associated diseases. These identifiers link to their respective sources, for instance, the OMIM phenotype entry. If you prefer to start with your favorite human gene, use the template: “Human gene to yeast homolog to OMIM disease phenotype”. You can then type in your favorite human gene, Or choose a gene list you have created and retrieve all associated OMIM disease phenotypes and homologs in yeast, as demonstrated here. The results table contains the same types of information as a previous search. The template “OMIM disease phenotype to human genes to yeast homologs” lets you begin with either a disease keyword or a specific OMIM phenotype, and retrieves the associated human genes and their counterparts. For instance, you can search for the keyword “diabetes”, an exact term, or your own phrase. You will then retrieve a list of human genes and their potentially interesting yeast counterparts. Create a list of your desired yeast genes and save them as a list for further analysis using other templates. You can also quickly look at the GO, pathway, and publication enrichment widgets among others for this list. Lastly, you can find fungal homologues for a given S. cerevisiae gene using the “Gene to Fungal Homologs” template. The data for 24 different fungal species are searched and returned, providing gene identifiers that link to their original source. Please contact us here at SGD with any questions or suggestions at: [email protected]

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