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Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown

March 10, 2020


kram welcome to another MedCram kovat
19 update we see here that the total recovered is sixteen times that of the
total deaths and we can see here that the active cases are once again starting
to come back up again that’s because of the activity outside of China in terms
of today March 10th we can see that there’s a number of cases in multiple
countries all over the world and of course the news from yesterday is that
Italy has decided to extend its lockdown to not just the north of Italy but to
all of Italy in terms of yesterday in Spain the number of cases have
essentially doubled with 557 new cases and that seems to be a new hot spot I can tell you as of yesterday I was
able to get a lab test out of a commercial test company that I needed to
have done in a patient in the emergency room so I’m hoping that that is going to
increase dramatically here in the next week or so we’ve talked about zinc here
a couple of updates ago but the story is not done it’s kind of
an exciting story that gives me some cautious optimism in terms of kovat 19
but to understand this better we’ve got to go back and look at the molecular
biology of the cell once again here is the nucleus of the cell and the nucleus
of the cell is the DNA the DNA is a double-stranded string of nucleotides
which are the codes those codes are transcribed using RNA polymerase into
RNA that RNA then goes out of the nucleus gets a 5 prime cap and gets a 3
prime poly a tail and it’s ready for ribosomes to come on to read that code
and that code is then translated into the code of amino acids which amino acid
after amino acid will turn into a polypeptide which turns into a protein
and proteins are how the cell gets things done so it moves by proteins
actin and myosin it can bind oxygen through hemoglobin it can do cellular
metabolism all of those enzymes in glycolysis in the citric acid cycle all
those things that you learned in biochemistry those are all enzymes those
are all proteins so that’s the normal situation now enter coronavirus
coronavirus has its own genome it is made out of RNA and that RNA just
happens to have a five-prime head and a poly a tail so when it pops into the
cytosol it’s going to be read by those same ribosomes that can’t tell the
difference except this time instead of making a
that’s useful to your cell this RNA that comes out of the virus is going to make
something called a RNA dependent RNA polymerase and it’s this enzyme right
here that is going to read from the three prime m to the five prime end of
the viral RNA and replicate it so this RNA dependent RNA polymerase makes more
viral genomes it’s also known as replicase for that reason and there’s
something that has been shown to inhibit this replicase and that is zinc zinc
will shut down RNA dependent RNA polymerase or replicase and so that is
what we learned the problem is how do you get zinc inside the cell the problem
with zinc is that it’s an ion it’s a 2 plus ion and ions cannot get through the
cellular membrane unless there’s a transporter that allows it to come in in
fact the way that they tested this in the paper is with an Iona 4 which allows
the zinc to come into the cell so they could see that the activity of this RNA
dependent RNA polymerase was reduced this is the paper zinc inhibits
coronavirus RNA polymerase activity in vitro and zinc ionophores blocked the
replication of these viruses in cell culture when they looked at the SARS cub
virus that was the one that was seen back in 2002 as the zinc concentration
inside the cell went up you can see that the byproduct of the RNA dependent RNA
polymerase went down down down clearly demonstrating that zinc intracellularly
is going to block this very important enzyme of the virus well that’s great
we’ve got zinc that’s gonna block it but how we get zinc inside the cell it’s one
thing to say that you’re gonna take zinc supplements but how do those zinc
supplements first of all get absorbed into your body in
the blood into the extracellular space and then finally how are you gonna get
that zinc from the extracellular space into the intracellular space in the
cytosol where it needs to work on these infected cells and these viral proteins
well that’s another thing altogether what you need is some sort of ionophore
or some sort of gated mechanism to open and to allow that zinc to come into the
cell increasing the concentration of zinc into the cell so it can block Rd RP
well enter this paper that was pointed out by some of you commenting
chloroquine is a zinc ionna for this paper was published back in 2014 and the
point of this paper was something completely different they weren’t
thinking about coronavirus they probably didn’t even know perhaps that zinc
blocks RNA dependent RNA polymerase what they were looking at here is that zinc
may help some of these cancer cells basically eat themselves in the
lysosomes which are sort of trash compactors of the cell and that by
giving chloroquine you could have these cancer cells disappear well in doing
that research they found out something that’s very interesting to us because of
that finding and this research came out of the University of Oklahoma and some
institutions in China so this is what they used chloroquine diphosphates
here’s the structure of that compound and this chloroquine is a medication
that has been around for decades that is used to treat malaria it’s not under
patent and it’s pretty dirt cheap and widely available however you do need a
prescription to use this and it doesn’t come without side effects what they show
is that they were able to detect intracellular zinc by checking its
fluorescence here on the x-axis we have increasing concentrations of chloroquine
and the white bars represents those cells that were bathed in only five
micro molar solution of zinc chloride and the black was in ten times that
amount at 50 micro concentration of zinc chloride and what
you can see here is that in the normal situation if you’re able to get some
zinc into the cells this is the amount of zinc you’ll see inside the cells so
this is the amount of concentration outside the cell this is the amount of
zinc you see inside the cell and let’s just look at this same concentration 5
micro molar when you bathed the cells in chloroquine you can see how much this
intracellular sink concentration goes up in fact if you look at the amount of
zinc inside the cell by just adding a small amount of chloroquine here at 10
micromolar we would get more zinc inside the cell than if we increase the
concentration of zinc outside the cell tenfold
that’s how powerfully chloroquine will increase intracellular zinc
concentration now remember this is chloroquine this is a medication that’s
been used by millions of people already with known side effects and it’s pretty
well tolerated here’s another example from the article here we have the
control group the 5 micro molar of zinc chloride and then what we do is we
multiply that extracellular zinc concentration tenfold so it’s now 50
micro molar and so this would be the equivalent of just saturating the
extracellular fluid compartment with zinc and see if it tries to get into the
cell which is what you’re trying to do when you take a zinc lozenge essentially
and you can see there’s hardly any effect it’s minimal and that’s because
zinc is a ion it’s a positively charged ion and positively charged ions will not
get into the cell unless there is a gate that allows it to go in and there is
gates that allow it to come in that’s how it’s very tightly regulated but
chloroquine activates those gates and so you can see this is at 50 micro moles of
zinc chloride we can go back to the 5 micro moles here but just adding 300
micro moles of chloroquine lights this thing up like a Christmas tree and you
can see here if we go to 50 again it lights up even more
but the biggest effect is not the jump in the zinc concentration it’s opening
those gates that allows you to get the zinc into the cell and presumably when
that zinc gets into the cell it’s gonna block that viral enzyme and in the
discussion we’ve got the conclusion of the matter the conclusion that
chloroquine is a zinc ion of four is based on the detection of significantly
elevated intracellular zinc levels when both zinc and chloroquine were added to
the cell culture medium so the question is is this being used and to that I turn
to Korea biomedical review physicians work out treatment guidelines for
coronavirus notice that this is published here on the 13th of February
when they were starting to see an uptick in their cases in Korea and the article
goes on to say Korean physicians treating the patients infected with the
new corona virus kovat 19 have established the treatment guidelines for
the unprecedented iris the key guidelines are the following if patients
are young and healthy then they will be observed if more than 10 days have
passed since the onset of the illness they’ll continue to watch them but
notice what happens if the patients are old have underlying conditions or sick
and have symptoms they say here for antiviral treatment the doctors
recommend lopen of air and retina ver this is basically the medication Calitri
which is an HIV medication and they recommend two tablets twice a day or
they can use chloroquine 500 milligrams per day orally in Korea chloroquine is
not available so they use a very close relative of chloroquine which is
hydroxychloroquine and that’s at 400 milligrams orally per day now the reason
why you would not want to use both is because they interact with each other in
a negative way in terms of prolonging the QT interval for those of you who
don’t know what the QT interval is this is a measurement of electrical
conduction in the myocardium in the heart and if the Qt becomes too
prolonged you can get fatal cardiac arrhythmias in this article they do talk
about the antiviral treatment thing about seven to ten days but it
could be shortened or extended and here is one of the keys that I want to
mention this is all being used empirically we don’t have randomized
controlled trials looking at chloroquine in patients with kovat 19 that being
said there has been some publications interestingly coming out of China which
do tout the efficacy of chloroquine now I have to say at this point that it’s a
little bit interesting that that’s happening from my standpoint and from
the standpoint of somebody who understands what a randomized controlled
trial that’s blinded says because if you are truly doing a blinded study you will
not be able to tell if an intervention is working or not that’s the whole point
of a blinded study and that is to avoid bias for instance if you know that
someone’s getting the intervening choice you might be doing a better job of
taking care of that patient without even knowing it so it’s a little interesting
to hear that there may be some efficacy some improvement in some of these
patients unless it was a unblinded study and if it’s a unblinded study then it
has to be taken with a grain of salt and that’s why we really need a randomized
placebo-controlled double-blind ‘add ideally type of study anyway here is an
article that is indexed expert consensus on chloroquine phosphate for the
treatment of novel coronavirus pneumonia this was published in February 2020 and
says here at previous studies have shown that chloroquine phosphate or
chloroquine had a wide range of antiviral effects including anti
coronavirus here we found that treating the patients diagnosed as novel
coronavirus pneumonia with chloroquine might improve the success rate of
treatment and improve patient outcome in order to guide and regulate the use of
chloroquine in patients with novel coronavirus pneumonia the multicenter
collaboration group developed this expert consensus it is recommended
chloroquine phosphate 500 milligrams twice per day for 10 days for patients
diagnosed as mild moderate and severe cases of coronavirus pneumonia and
without contraindications to chloroquine so interestingly the Koreans
are using according to the literature once a day and the Chinese were using it
twice a day now that is all to say if we look at South Korea numbers and of
course we know that they have extensively tested and this is my
hypothesis if you extensively go out and try to find as many cases as you
possibly can and then you set up a standardized treatment regimen and get
people on that regimen early you can see here that even though Italy and South
Korea have very similar total cases the number of deaths is an order of
magnitude difference the number of serious and critical is more than an
order of magnitude different between them and one has to wonder either the
tip of the iceberg is much much smaller on a very very large iceberg in terms of
Italy or there is some sort of systematic treatment difference between
what is going on in Italy and what is going on in South Korea at this point I
don’t know how widespread chloroquine use is in Italy but it’d be interesting
to find out we’ll end on this where they talk about the trials of coronavirus
data from the drug study showed certain curative effect with fairly good
efficacy Chinese National Center for Biotechnology development deputy head
son Yin Rong said that chloroquine an anti-malarial medication was selected
after several screening rounds of thousands of existing drugs according to
son patients treated with chloroquine demonstrated a better drop in fever
improvement of lung CT images and required a shorter time to recover
compared to parallel groups the percentage of patients with negative
viral nucleic acid tests was also higher with the anti-malarial drug chloroquine
has so far showed no obvious serious adverse reactions in more than 100
participants in the trials so getting back to our idea here of what’s going on
in molecular we’ve got sink here that needs to shut down RNA dependent RNA
polymerase and what we’re saying here is that chloroquine
is gonna somehow open up this ion gate and allow the zinc to come in to block
and shut down viral replication inside of the cells I think that’s exciting
I am cautiously optimistic that this may lead to something but again I have to
stress that we need randomized control trials to prove this many times we come
up with ideas that make sense and look like they should work but the proof is
in the pudding and we need to do the randomized control trial we’ve got a lot
more areas to hit on this coronavirus one of the things that we’re going to
look at is the ACE 2 receptor have a lot of questions about the ACE 2 receptor
we’ll talk about that in upcoming updates

100 Comments

  • Reply MedCram - Medical Lectures Explained CLEARLY March 10, 2020 at 6:09 pm

    Please support our daily COVID-19 updates by subscribing and visiting us at https://www.MedCram.com Thank you!
    At our website, we offer CME/CEUs for medical professionals and CLEAR explanations of over 60 medical topics.
    All links referenced in this video are in the video description.
    Quick links to our other videos on this coronavirus epidemic:
    – Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74
    – Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U
    – Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk
    – Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: https://youtu.be/gmqgGwT6bw0
    – Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: https://youtu.be/XjEacUyp4vY
    – Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: https://youtu.be/quDYb_x54DM
    – Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: https://youtu.be/xQwfuJgJ9lo
    – Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? https://youtu.be/bV1CZxJ-uvU
    – Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends: https://youtu.be/UImSVhLLeGY
    – Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: https://youtu.be/wFoj2L2LpNA
    – Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: https://youtu.be/JGhwAGiAnJo
    – Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: https://youtu.be/OqpHvK0XADY
    – Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: https://youtu.be/9BYaywITXYk
    – Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: https://youtu.be/Ka48UZDDzLY
    – Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: https://youtu.be/4HK9QEy1KJ8
    – Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: https://youtu.be/vE4pBkslqS4
    – Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): https://youtu.be/wlbM6VVkVZM
    – Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): https://youtu.be/qqZYEgREuZ8
    – Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): https://youtu.be/o804wu5h_ms
    – Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: https://youtu.be/pDnmHu8x9C4
    – Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: https://youtu.be/0UgrPgJdzp0
    – Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: https://youtu.be/GT3_A1bf9pU
    – Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): https://youtu.be/pfGpdFNHoqQ
    – Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): https://youtu.be/gPwfiQgGsFo
    – Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: https://youtu.be/8Hjy3UfaTSc
    – Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: https://youtu.be/GpbUoLvpdCo
    – Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: https://youtu.be/nW3xqcGidpQ
    – Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: https://youtu.be/UGxgNebx1pg
    – Coronavirus Update 5: Mortality Rate vs SARS / Influenza: https://youtu.be/MN9-UXsvPBY
    – How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: https://youtu.be/okg7uq_HrhQ
    – Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: https://youtu.be/SJBYwUtB83o
    – Coronavirus Symptoms, Diagnosis, Treatment: https://youtu.be/UCG3xqtcL3c
    – Coronavirus Outbreak – Transmission & Updates: https://youtu.be/9vMXSkKLg2I

  • Reply Matthew Clegg March 10, 2020 at 9:15 pm

    Come back Zinc… Come back!

  • Reply Arnold Horshack March 10, 2020 at 9:16 pm

    On Radio expert in a hospital suggested that test kit precursors are not available; another expert suggested that we have a two week supply of hospital protective garb and that we need ten times the current inventory. All these dependencies that are unfulfilled point back to china. I checked out target, the sun glass wall is empty.

  • Reply Dan Nicolae March 10, 2020 at 9:17 pm

    There is a virologist in France that wanted to promote clorochine, but nobody cares, he is made look ridiculous. So it seems only the chinese and the koreans want to save the vulnerable.

  • Reply no further west March 10, 2020 at 9:17 pm

    Can you do a video analyzing how Vitamin C might impact Coronavirus?

  • Reply Intuitive Sean March 10, 2020 at 9:18 pm

    Would Iv of zinc get into the cell or does the gate have to be opened by chloroquine?

  • Reply Daniel Glaubitz March 10, 2020 at 9:20 pm

    Excellent! Let's hope so!

  • Reply Andy Tang March 10, 2020 at 9:21 pm

    Thank you, very interesting and educational video, promising developments on possible treatments

  • Reply MZ March 10, 2020 at 9:21 pm

    Gotta get me some chlorquine and zinc supplaments before they vanish off the shelfs

  • Reply juancarloscafe1 March 10, 2020 at 9:21 pm

    You should go on Infowars.

  • Reply Jolly BeGood March 10, 2020 at 9:22 pm

    What about flu (influenza) ? Will this chloroquine and zinc combo help there ?

  • Reply boB Gudgel March 10, 2020 at 9:24 pm

    Why is it that the Korean and clinical trials sites talk about chloroquine but do NOT mention zinc ?

  • Reply Gerard March 10, 2020 at 9:25 pm

    update
    sewersystems spread it
    i thought of it first
    but enjoy
    we have made progress

  • Reply Charles K March 10, 2020 at 9:25 pm

    Coronavirus PANDEMIC…

  • Reply Alex M March 10, 2020 at 9:27 pm

    Thanks for all your hard work not only in passing along this info but treating all the patients. They are lucky to have a doctor that does his research and is obviously very dedicated. May you be kept healthy and safe throughout all this chaos.

  • Reply James Russell March 10, 2020 at 9:28 pm

    Very promising steps in science to fight Corona virus

  • Reply B. K. March 10, 2020 at 9:30 pm

    Why aren’t USA not using this until we get vaccines?

  • Reply George Burns March 10, 2020 at 9:30 pm

    The Britains used Quinine in there Gin to treat Melaria…any similarity?

  • Reply Love And Light March 10, 2020 at 9:30 pm

    Not to be negative but who manufactures these drugs? I do not think it is the US.

  • Reply Julie Le March 10, 2020 at 9:32 pm

    MedCram is my primary source of information about Covid19. Thanks Doctor 👍

  • Reply Teresa lane March 10, 2020 at 9:33 pm

    Heard about chloroquine working on this virus about a week ago, been waiting for some confirmation. Thank you!

  • Reply Senior Adrian March 10, 2020 at 9:33 pm

    Thanks for the information. Well explained. Keep us updated.

  • Reply LAJ March 10, 2020 at 9:33 pm

    Thank you. Exciting. What about a liposomal Zinc to the cells?

  • Reply ROCK YOUR NATURAL March 10, 2020 at 9:33 pm

    The best news I've had since 2020 started.

  • Reply Dhanraj Mohan March 10, 2020 at 9:35 pm

    Public comments. Lack of deficiencies can affect your health it is important to build your immune system by eating healthy food like fresh organic vegetables and fruits and fresh fish . cleaning up your environment that you dwelling do not touch your face before washing your hands . always remember to wash your hands before eating anything. Please do not touch filthy places and do not stay in large crowd by very careful with your health it is vital for your survival. God bless all humanity ,stay safe with your family 🙏❤️🙏.peace and love

  • Reply Big Z March 10, 2020 at 9:36 pm

    WE NEED TO COLLECT ALL THE ZINC LIKE DR. DOOFENSHMIRTZ IN PHINEAS AND FERB!

  • Reply Nocturne March 10, 2020 at 9:36 pm

    Excellent video. Unfortunately, I think this medication is prescription only, so I doubt my doctor will give me this based on a youtube video. Looking forward to your video on the ACE2 receptor, I do believe some blood pressure medication can inhibit this receptor based on preliminary research.

  • Reply sixtyinsix March 10, 2020 at 9:37 pm

    Could you use DSMO in place of chloroquine?

  • Reply JJ France March 10, 2020 at 9:37 pm

    Flu symptoms – neti pot saline wash of sinuses followed by zicam swabs in nasal passages. Kicks flu in the butt every time.

  • Reply Facts don't care about your Feelings March 10, 2020 at 9:38 pm

    500mg a day,, but how much zinc do I take with that. Thx 😉

  • Reply Kelvin Ham March 10, 2020 at 9:38 pm

    Excellent information again. Important to keep people informed and treating them as though they have some level of intelligence.

  • Reply David Johnson March 10, 2020 at 9:39 pm

    If positive results are indeed obtained then chloroquine should be used. Most patients especially those with weak immune system need something to get them better.
    I have seen some videos from China where doctors were somewhat optimistic. Zinc level is hard to increase with average diet unless someone likes pumpkin seeds.
    Zinc orotate shows best promise of increasing zinc blood level. Trying zinc orotate with chloroquine twice a day should be interesting. China is conducting studies
    on Vitamin C IV therapy using 12,000 mg and 24,000 mg. Doses of 1 gram per kg of body weight have been tried before for various conditions. Vitamin C has anti-viral
    and anti-bacterial properties.

  • Reply sheryll nito March 10, 2020 at 9:39 pm

    There’s hope!!! Hope the world will learn from South Korea and China on how they battled Covid2019.

  • Reply Thomas Kreuzer March 10, 2020 at 9:40 pm

    We will have shitload more of all kinds of deadly viruses stored for thousands of years and now coming out with the ice melting,

  • Reply J H March 10, 2020 at 9:41 pm

    Thank you for the update 👍🙏

  • Reply Kilnmaster March 10, 2020 at 9:41 pm

    So because china (behind its facade) is a leader in pollution related deaths and disease incubation but gives the RMB to every countries in forms of bribes we should let them slide? They are killing the world.

  • Reply Gazer 878 March 10, 2020 at 9:41 pm

    Has anyone seen any research about the behavior of covid-19 at freezing?

  • Reply The Still Report March 10, 2020 at 9:42 pm

    Pardon me Dr. Seheult, I wrote most of this as a comment on my own site first before I came back to your site to post my stream-of-consciousness here too. I did the very first story for the lay audience on zinc lozenge treatment for colds and flu with using zinc tablets as a lozenge. I interviewed the main author of the study and university-affiliated colleagues who agreed with his findings. This would have been somewhere between 1986-88. It was shown at that time that the zinc DID SHUT DOWN the replication of the virus in the mouth and throat when it was in direct contact with the virus. That gave the immune system a chance to manufacture whatever was needed and catch up to the virus replication ability. Dr. Seheult seems to be unaware of this. However, once the zinc got into the gut, it no longer became effective for the reasons Dr. Seheult states more than likely. But you seem to believe that zinc lozenges for virus is a farce. I can tell you from personal experience that it is not a farce. It has worked well for me and my family ever since. It doesn't shut the virus down instantly, but as the original study showed that it cut the recovery time from colds or the flu by something like 25-50%. Which makes sense. Now Dr. Seheult's idea is to use the anti-malaria substance with the zinc so that the zinc then enters the cell after it leaves the mouth/throat. Sounds right to me. This could be the solution to COVID-19 and even more importantly what may come next.

  • Reply Doranne Renga March 10, 2020 at 9:42 pm

    In reference to Chloroquine; those with autoimmune diseases can not use this drug.. "Several patients with autoimmune diseases, Myasthenia gravis (rheumatoid arthritis and SLE)

    developed clinical, physiologic, and pharmacological evidence for MG after prolonged use of chloroquine. These

    patients had AChR antibodies which eventually disappeared, as did the other abnormalities following

    discontinuation of the drug." so if a person Has MG this drug can cause a MG crisis .. which included not breathing as MG is a muscle disease which paralyses all muscle function.. So those with AChR antibodies this drug is deadly .. which is me lol!

  • Reply Gerard March 10, 2020 at 9:43 pm

    think of me as a cumulating bank
    with data
    star trek like
    we will get
    we are getting
    we do what we can
    except for the europeans and americans
    720 comments on this episode is ridiculously low
    i value you all 100%

  • Reply chad cooke March 10, 2020 at 9:43 pm

    Love the silence when it comes to US, the land of the free home of the brave. I pray for us all

  • Reply Philip J. fry March 10, 2020 at 9:45 pm

    Where do I get this map?

  • Reply Hiroshi loves You March 10, 2020 at 9:45 pm

    spread the word 📣

  • Reply Bo Lawrence March 10, 2020 at 9:46 pm

    Great information! I hope you carry this kind of education moving forward. This can be like threading a needle and connecting the dots.
    My wife is a MD, PhD. If she could only break it down like this. I actually forward your info to her.

    I would think that as many subscribers you have you could do a fund me page to conduct your own studies.

    Keep up the good work!

  • Reply dennis n March 10, 2020 at 9:46 pm

    It's people like you that gives the world hope. Keep up the fantastic work. We'll be standing by for your next update. God speed and god bless.

  • Reply Hannibal EnemyofRome March 10, 2020 at 9:46 pm

    Nice, sir, nice!

  • Reply mitzvah golem March 10, 2020 at 9:46 pm

    Would Zinc metallic vapor be able to enter cells of lungs?
    Or would it be rejected as an antigen?
    Just a thought

  • Reply SabreTwo190 March 10, 2020 at 9:47 pm

    This is promising, but the studies & trials need to be fast tracked.
    We also need a vaccine! I would love to see a video on how thats being produced

  • Reply Paris Roussos March 10, 2020 at 9:47 pm

    Would quinine increase intracellular zinc?

  • Reply JJ France March 10, 2020 at 9:47 pm

    Missed it on the Italy S Kor comparison. SK is aggressively testing for Kovid which explains the statistic.

  • Reply Thomas Livingstone March 10, 2020 at 9:47 pm

    Interesting, thanks for thi, not that I can really understand, but you do make a good case for there being more effective treatment in s korea

  • Reply WierdSpookyDude March 10, 2020 at 9:48 pm

    Awesome lecturer! You do a great job of making the complex more understandable to the layperson. THANKS!

  • Reply Andrew Baumgartner March 10, 2020 at 9:48 pm

    Italian lock down?!? There's still flights entering and leaving the country as if nothing were.

  • Reply the guy the name March 10, 2020 at 9:49 pm

    Colloidal silver ions can bridge and break through the blood-brain barrier.

    It can do so without causing damaged including bacterial and viral inhibitor.

  • Reply Xiaoguo Ge March 10, 2020 at 9:49 pm

    Death rate in China should be devided into two segments: within Wuhan and outside of Wuhan. Within Wuhan, there was serious mismanagement and hospital bed shortages that death rate was once as high as 10% initially which measurement of treatment effectiveness should not be based on.

  • Reply Alexander Simpson March 10, 2020 at 9:49 pm

    What about quinine found in Indian tonic water and some drinks? Would there be a benefit of drinking Indian tonic water and taking zinc along with copious amounts of vitamin c as a antiviral?

  • Reply Daniel Murphy March 10, 2020 at 9:51 pm

    There seems to be a shortage of test 'kits'. Why can't blood from several (or many) people be combined and tested using only one test kit? If positive for the virus then each could be tested individually. If negative, you've saved some test kits.


    I'm sure someone has thought of this but, I have a student asking why it can't be done.

  • Reply Vash TheStampede March 10, 2020 at 9:52 pm

    New state with a case in America today Albuquerque NM has it's first case.

  • Reply Bob Thrasher March 10, 2020 at 9:52 pm

    What about liposomal zinc? Could the Chloroquine be avoided in this case? Ionophore definition: An ionophore is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across a cell membrane.

  • Reply MaxThriving March 10, 2020 at 9:52 pm

    All of you should be proud of the way you work together to provide info that is available and understandable to so many of us. Good Job!

  • Reply Tyler Amzona March 10, 2020 at 9:55 pm

    The best channel for your daily update. Thank you all who work on this!!! And please stay safe, healthy and strong. Bless you, all worldwide !! All the best from the Netherlands

  • Reply fedor p March 10, 2020 at 9:56 pm

    Maybe dumb it down a bit or have two videos. That one screen with the virus makeup and everything's a bit much. I followed probably 15 of these videos but zoned out the last time you explained that stuff and my brain doesn't want to process that much at one time.

  • Reply John Doe March 10, 2020 at 9:57 pm

    A bit technical for some maybe, but I'm finally getting some mileage out of those molecular biology classes of 25 years ago. 😉

  • Reply G T March 10, 2020 at 9:57 pm

    MEDCRAM – Number one medical information video

  • Reply The420 Jamaican March 10, 2020 at 9:58 pm

    Sigh, Jamaica’s first case today, a female that traveled back from United Kingdom March 4th & March 10th was confirmed to have covid -19

  • Reply Shawn miciotto March 10, 2020 at 9:58 pm

    So could you use quinine or tonic water and zinc ?

  • Reply KrisKi March 10, 2020 at 10:00 pm

    Thank you so much for your work!!! Greetings from Portugal 👌🏼👌🏼👌🏼

  • Reply Buck Schneider March 10, 2020 at 10:00 pm

    Should i take chloroquine pre or post infection?

  • Reply Wounded Lion March 10, 2020 at 10:02 pm

    Thank You MedCram!

  • Reply Henry Ho March 10, 2020 at 10:02 pm

    I heard about this chloroquine phosphate treatment about 3 weeks ago from a Chinese channel in US that on the comments section someone recommended to use it and it was readily available at the counter of the pharmacy at a low cost of Yen 20 about US$3.-. Because the hospitals in Wuhan could not handle so many patients and they were asked to stay at home and wait and finally died. The commentator of that channel suggested that people who contracted this coronavirus and were seriously ill if they wished they might try it and gave a feedback. After a few days, patients said that they were getting better each day. The Chinese govt tightened the media many people couldn't get this info.

  • Reply poco loco March 10, 2020 at 10:03 pm

    Godbless you guys. Thanks for sharing your expertise.

  • Reply Damon March 10, 2020 at 10:03 pm

    Take your vitamins. I’d assume that zinc is essential but how does it work in general without getting into the cell? Very interesting.

  • Reply Lisa S March 10, 2020 at 10:03 pm

    I want that graphic on a t-shirt. Lol

  • Reply Islamisthecultofsin March 10, 2020 at 10:04 pm

    This needs to be sent out to all of the news channels and health officials. They should be doing the randomized trials now!

  • Reply K Poper March 10, 2020 at 10:07 pm

    Thank you, Doctor. It is very informative. I've learned a lot and sincerely hope that nations try chroloquine to fight the Covid19 just as the Korean doctors do.

  • Reply Ali Taghavi March 10, 2020 at 10:08 pm

    Thank you for these fantastic videos!! So informative

  • Reply Word Carr March 10, 2020 at 10:08 pm

    How come the paper quoted doesn't say anything about the compound and use of Zinc? In other words, the 500 mg of Chloroquine per day or twice a day doesn't list anything about taking a compound of Zinc as part of the daily regimen?

  • Reply Lance Tschirhart March 10, 2020 at 10:09 pm

    What is this awesome gray and black and red map software for COVID-19? I really want to use that.

  • Reply Tom Terific March 10, 2020 at 10:12 pm

    From the data presented here, is it reasonable to propose that if a patient has a normal dietary intake of zinc, then no further zinc supplementation is needed as long as they're getting chloroquine?

  • Reply Kath Bowring March 10, 2020 at 10:14 pm

    Thank you! Totally Exciting! Question for you- Does it work with calcium ions for your bones also? Thnx

  • Reply André Balsa March 10, 2020 at 10:14 pm

    Brilliant explanation of how chloroquine could work as a treatment for the novel coronavirus. Btw the news here in France is that coronavirus patients in Marseille are going to be clinically treated with chloroquine. So testing is already underway in France.

  • Reply Sidonie Winter Pasternak March 10, 2020 at 10:14 pm

    It is quite easy to impose a quarantine for example in Korea because the people there are more obedient and disciplined than here.

  • Reply Andrew Wilson March 10, 2020 at 10:16 pm

    amazing video discussing malaria medicine and covid-19

  • Reply C A March 10, 2020 at 10:16 pm

    Thank you very much for these detailed explanations. At IHU Marseilles Professor Didier Raoult a well known biologist, specialized in infectious diseases, is very familiar with chloroquine, has used it for years for different pathologies, he believes in this medication, he is currently conducting a hydrochloroquine test on coronavirus patients. Lets hope for the best

  • Reply Suzanne De Assis March 10, 2020 at 10:16 pm

    What if you drink tonic water and take zinc?

  • Reply David Armstrong March 10, 2020 at 10:16 pm

    Thanks for all your work in reporting sound science.

  • Reply Clothed Ape March 10, 2020 at 10:17 pm

    It's all about miney. They have had 102 years to find a cure – anti-virals since the last big pandemic. But there's no profit in finding a cure for something that only happens every 100 years.

  • Reply Joe Walkalone March 10, 2020 at 10:17 pm

    EXCELLENT!

  • Reply gary lin March 10, 2020 at 10:18 pm

    Great!!!! News…. Best novel knowledge…. This is a very good news information for special who in Italy and Iran people safe life and to tell all Coronavirus COVID-19 is effecting many countries.

  • Reply Rob March 10, 2020 at 10:19 pm

    Exchanging scientific data was the reason for the internet to begin with and was in effect in the 60’s for this reason.

  • Reply david NY March 10, 2020 at 10:22 pm

    Wow God bless you the time you spend putting this info together is absolutely fantastic. Here in NY the Gov has decided to quarantine a part of New Rochelle.

  • Reply Boonedock Journeyman March 10, 2020 at 10:25 pm

    Not a bad job. But remember that the data showing for an Investigator Sponsored trial has nothing to do with making public claims of efficacy to the masses.

    You will have killed fewer people by heart failure with this video only to the degree that they are capable and willing to understand your concluding remarks about trials.

    What is your particular Board’s rule on “encouraging” non-expert patients to do what an Investigator Package would be required of you to dose?

    I spent my 35 year career in RNA virus drug design and development. I watched countless patients die trying to “treat” HIV with dextran sulfate and ex-corporeal thermo-treatment of blood.

    If you don’t lose your license, know that you will be morally responsible for the sort of horror I witnessed.

    May you be damned for those you injure and kill with your insatiable ego.

  • Reply Casey C March 10, 2020 at 10:26 pm

    Could you compare the age of confirmed cases between Korea and Italy?

  • Reply Tmb1112 March 10, 2020 at 10:27 pm

    YouTube loves to promote WHO prop and MSM uneducated discussions and announcements from politicians intentionally lying to push agendas of avoiding panic, when the best way to avoid panic would be if they just told us the truth like MedCram and Dr. Campbell. An educated population feels safer. I feel safer watching these videos, then I look at everything else on the disease and the idiotic things the people in power and who reach the most people are saying, and it's actually what's scary.

  • Reply Global Healing March 10, 2020 at 10:30 pm

    Ty 4 your time and information. I have used Zinc Picolinate 300 mg a day for connective tissue ..and it works awesome I am 64 y young and in awesome health my immune system is healthy.
    You are correct on this info .
    I Am integrative medicine practitioner holistic approach to health for 40 years.
    Longevity is #1 on agenda…Bravo and ty. .keeping humanity from panic by transformational info…
    Sincerely; Dr Mila

  • Reply Hemang Patel March 10, 2020 at 10:31 pm

    What are the chances of this treatment being used in the US as well or is it already being used in the US?

  • Reply Wednesday's Child March 10, 2020 at 10:31 pm

    Perspective people…It's a strange pneumonia and the regular treatment doesn't work. Italy asked people not to go to hospital unless they are unable to breathe.

  • Reply Lew Google March 10, 2020 at 10:33 pm

    Note that in the case of the Coronavirus, in the paper quoted, the replication of viral RNA never really goes to zero or to below the level of detection of the blot. This does not bode well for its effectiveness in human disease.

  • Reply trebled99 March 10, 2020 at 10:36 pm

    SHUT DOWN ALL AIRPORT NOW AND LET EACH COUNTRY DEAL WITH WHAT CASES THEY HAVE

  • Reply Reno Reins the BH March 10, 2020 at 10:36 pm

    I am just so sick of people talking about how government suck, WHO corrupt, why you not call it pandemic, why not close borders etc. etc.
    What's your point, what you trying to say or achieve? Keyboard warrior talk as if it was all so simple, like press of a button. Not to mention that world is run by money since forever, what do you expect. And none forces you to listen to them. This channel is great example, why all these toxic statements are utterly meaningless. Internet is full of information to literally anything you can imagine. This outbreak shows extend of moral decay, beyond my wildest imagination. I used to believe people can put aside their differences against global thread. Makes me wana thank god for low mortality rate, even though I am atheist.
    Chloroquine is my city

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