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Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention

March 5, 2020

welcome to another MedCram COVID-19
update we’ll do some updates and also talk about preparation from a prevention
standpoint here we have our Johns Hopkins dashboard at ninety four
thousand total confirmed cases total deaths thirty two hundred total
recovered fifty one thousand South Korea has the most confirmed outside of China
and we’re talking about aggressive testing in South Korea Iran quickly shot
up we can see here that’s a pretty large red dot we go to the world ometer
website active cases are actually on the decline probably because we are leaving
a epidemic in China but there are small epidemics relatively outside of China
that are rapidly growing and that’s why this is not continuing to go down if we
look at total cases we can see that the inflection point has started to turn
upwards let’s look at the latest updates a number of countries are reporting
single digits cases and in some cases some deaths interestingly here there’s
586 new cases in Iran but they’re also starting the show recoveries as well we
knew there would be recoveries but we’re just not seeing a lot at this point we
see that there are 10 new cases in Belgium nine of which came from northern
Italy and that seems to be a hotspot of spread throughout Europe remember that
in Europe there are free borders because of the European Union so it’s not as if
this is unregulated constrain travel at least as of a couple of weeks ago four
new cases in the United States all of them being in California which is a hot
spot there’s one in Los Angeles County two who had recently traveled to
countries that have had cava 19 and there’s one new case in Contra Costa
County in Northern California that second case of corona virus in Los
Angeles was reported by Fox 11 News that patient is being taken care of at home
in self isolation and being treated on an outpatient basis the purpose of May
cram and what we’re doing here is to talk about the data the raw numbers to
talk about the medical aspects of this virus and what we know is going
but of course there are things that are out there that are emerging that seemed
to have evidence but don’t quite fit with coronavirus at this point because
we don’t have the data at this point let’s face it we have no randomized
controlled trials for coronavirus Cove at 19 they just haven’t been performed
so we’re forced to look at things that may work vitamin D is one of those
things we don’t have any randomized control trials that show that supplement
with vitamin D works in kovat 19 but we do have data about vitamin D
specifically and so I think it’s interesting to go over I’ve gotten a lot
of comments from people about vitamin D and the potential use for the corona
virus and even though this paper here is for the influenza virus vitamin D is not
actually having an effect on the virus itself as far as we know it’s affecting
the hosts us our bodies our immune system and how they deal with the virus
so potentially might be something that is applicable to other viruses and in
this case the corona virus and if you’ve thought about this you’ll notice that
there’s a lot of talk about what will happen in the summertime to the virus
and a lot of the talk has been about heat and humidity versus dryness and I’m
wondering if there’s another angle on this because vitamin D could be
acknowledged as a quote seasonal stimulus as defined by our Edgar Hope
Simpson it would be crucial to prove it from a potential easy and cheap
prophylaxis or therapy support perspective as far as influenza
infections are concerned now this paper talks about how first of all vitamin D
is absorbed into the body and how it is metabolized the fact that it is a
vitamin you have to understand that we cannot generate or make vitamin D in our
own body but in fact we need ultraviolet radiation from the Sun to convert the
inactive form to the active form I’ve always had a special place in my heart
for vitamin D because that’s what I did in terms of my undergraduate research
working in organic chemistry and so you’ll know that vitamin D for those of
you studied the structure is a lipid soluble vitamin and so it’s possible to
overdose on vitamin D so you have to be very careful with it because it is fat
soluble now there’s a lot of talk about vitamin D in the immune system and how
it bolsters it but something that’s also very in
interesting about vitamin D is its possible role in infections and also it
has a suppressive anti-inflammatory process so in other words vitamin D can
turn things on and it can also turn things off it’s not unimodal and that is
something that could be very helpful especially in the immune response that
we see in kovat 19 remember that it’s the immune system that is going to
suppress the virus which is good but it’s also the immune system that could
cause this storm of cytokines that put your lungs into a RDS and could
potentially kill so what we want is a smart immune system an immune system
that takes care of the virus but doesn’t put us into an inflammatory condition
that could put us on a ventilator so is vitamin D the answer I have no
financial relationships with any pharmaceutical companies or companies
that make nutritional supplements in any way this study that was talked about
here in the Harvard Gazette may be what we are looking for here it says a new
global collaborative study has confirmed that vitamin D supplementation can help
protect against acute respiratory infections the study our participant
data meta analysis so a meta analysis is simply a study that looks at a whole
bunch of other studies breaks down the components and makes a super study out
of it so they took actually 25 randomized controlled trials with an N
number of 11,000 participants that’s a pretty sizable number this was published
in the British Medical Journal I will give you a link to that journal will
actually look through that most people understand that vitamin D is critical
for bone and muscle health Cisco’s Camargo of the Department of Emergency
Medicine at Mass General our analysis has also found that it helps the body
fight acute respiratory infection which is responsible for millions of deaths
globally each year remember this article was published
before coronavirus several observational studies with track participants over
time without assessing the specific treatment have associated low vitamin D
levels with greater susceptibility to acute respiratory infections I don’t
have to tell you that living in high latitudes especially in the wintertime
exposes you to the least amount of sunlight if you have the least amount of
sunlight you would conclude a corporately that your vitamin D levels
are generally going to be on the lower side while it’s possible that the
seasonal variation in the virus may still have something to do with the
survival of the virus outside the body but it may have more than we think to do
with the survival of the virus inside the body it is a postulate but it’s
interesting the meta-analysis of these trials which aggregate data from several
studies that may have different designs or participant qualifications also had
conflicting results and this really has been the issue for some period of time
some studies showed that there is a connection that makes vitamin D look
good in terms of preventing infections others not so good so to resolve these
discrepancies this research team out of Queen Mary University of London
conducted an individual participant data meta-analysis so what does that mean
they grouped all of these studies together and then they stripped it down
to each particular individual and that is very powerful producing what could be
considered a higher resolution analysis of the data from all the studies the
investigators found that daily or weekly supplementation had the greatest benefit
for individuals number one there was a benefit and number two it was the turtle
not the hare what I mean by that is it was the daily supplementation not the
huge doses of vitamin D if you got sick this makes sense the people who have the
lowest levels are going to have the best effect from supplementation and it cut
their risk of respiratory infection get this in half that is a significant
number and could reduce the Arnott or the replication number in viruses and
maybe the reason why we see these viruses disappear in the summer I say
May don’t have proof of that yet but it’s interesting all participants
experience some beneficial effects from regular vitamin D supplementation
administering a high doses of vitamin C did not produce significant benefits
this study was not funded by some nutraceutical company but was funded in
fact by the British National Institute of Health Research so let’s actually go
to that study it’s open access we’ll put the link in the description below this
is from the British Medical Journal that’s a very prestigious publication in
the conclusion vitamin supplementation was safe and it
protected against acute respiratory tract infection overall patients who
were very vitamin D deficient and those not receiving bolus doses experienced
the most benefit so if you go down to the raw data they have to come up with
cutoff points and for those of you who don’t know how to read studies let me
show you here a little bit what they’re looking at is how many respiratory tract
infections they receive so one step’ individual participant data men analysis
proportion of partisans experiencing at least one acute respiratory tract
infection first thing to do is to look at the very top one and that’s overall
how many trials twenty-five proportion with greater than one acute respiratory
tract infection and proportion with greater than one acute respiratory tract
infection in the intervention group and you can see that there was a difference
and what was that difference the adjusted odds ratio is where you want to
look there’s another way of looking at to
looking at p-values to see if there’s a difference between these two groups
those in the control group those in the intervention group and any p-value of
less than point zero five is considered to be statistically significant so you
can see here that a bolus dose of greater than thirty thousand
international units given had a p-value of 0.67 that’s greater than point zero
five therefore not statistically significant in other words a bolus dose
is not going to be helpful if the bolus dose wasn’t given you can see that was
very statistically significant so the question is how much should I take on a
daily dose well here it is daily dose equivalent if it was less than twenty
micrograms highly statistically significant if it was 2250 still
statistically significant however if you took more than 50 micrograms there was
no difference between that group indicating that a modest dose of vitamin
D every single day would be the best here’s more research in the study
showing all of the different individual studies and the proportion with greater
than one acute respiratory tract infection and you can see here where
they lined up relative to number one remember one being no difference if it
was less than number one with a 95% confidence interval less than one then
you could say that that was statistically significant and it was
weighted based on the number of patients in that study and finally we come to the
overall which is down here at the bottom p-value a point zero zero one you can
see that it lands less than one so if you scroll down to the discussion it
says vitamin D supplementation reduce the risk of experiencing at least one
acute respiratory tract infection and it talks about the grade of the data which
was very good the question though is why would a bolus dose of vitamin D be
ineffective and they talked about how the wide fluctuations of circulating 25
hydroxy vitamin D concentrations which is the starting material for the active
form in the body could this right activity of enzymes responsible for the
synthesis and degradation of the active vitamin D metabolite which is 125
dihydroxy vitamin d so my recommendation based on this data would be take a small
supplement of vitamin D every day and again we’ll put the links to these
articles in the description below


  • Reply MedCram - Medical Lectures Explained CLEARLY March 4, 2020 at 7:15 pm

    Please support our daily updates by subscribing and visiting us at Thank you!
    We offer CME/CE and clear explanations of pulmonary embolism, antibiotics, EKG interpretation, and over 60 other topics.
    All links referenced in this video are in the video description.
    Quick links to our other videos on Coronavirus (COVID-19):
    – Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran:
    – Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate:
    – Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases:
    – Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic?
    – Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends:
    – Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms:
    – Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats:
    – Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing:
    – Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?:
    – Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins:
    – Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials:
    – Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips:
    – Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19):
    – Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19):
    – Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19):
    – Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks:
    – Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada:
    – Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV:
    – Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine):
    – Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV):
    – Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate:
    – Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA:
    – Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding:
    – Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period:
    – Coronavirus Update 5: Mortality Rate vs SARS / Influenza:
    – How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:
    – Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine:
    – Coronavirus Symptoms, Diagnosis, Treatment:
    – Coronavirus Outbreak – Transmission & Updates:

  • Reply Jojo 🇺🇸🇬🇭 March 5, 2020 at 1:44 pm

    Even though it’s real name is Covid-19 the cure or best prevention is in its name “CORONA” corona tends to mean SUN (which provides VD) in some languages and the word “Corona” is often associated with the sun. Or maybe I’m wrong lol I dont know 😂 just a hypothetical observation

  • Reply Mabel Elamparo March 5, 2020 at 1:45 pm

    Is it possible that a person can be positive with the flu and the covid 19 at the same time ?

  • Reply George Gould March 5, 2020 at 1:50 pm

    Do they separate the data based on ethnicity? Race? Gender? I read something that said certain races are less susceptible to Corona, is that true?

  • Reply 3D-4U March 5, 2020 at 1:51 pm

    Here's my question (I'm a physicist not a MD), is there a dose – mass dependency? Say 20 ug gives statistically the best results for an average built person? Should this be adjusted per kg or lbs?

  • Reply F Y March 5, 2020 at 1:54 pm

    so like? one orange?

  • Reply Dannie March 5, 2020 at 1:55 pm

    China stopped posting reports
    Hence the slower climb

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  • Reply William Stone March 5, 2020 at 2:20 pm

    A large body of evidence suggests ARDS pathology is due to excessive production of reactive oxygen species (ROS). Since glutathione (GSH) is the major intracellular antioxidant (mM levels!!) it is reasonable to suggest that oral N-acetyl-cysteine (NAC) could be effective.

  • Reply HappyCat3096 March 5, 2020 at 2:24 pm

    If you supplement with Vitamin D make sure you also take vitamin K to prevent calcification of your arteries.

  • Reply Celeste Marigold March 5, 2020 at 2:28 pm

    Finally someone mentions vitamin d … 🧸💖

  • Reply Sean Tendler March 5, 2020 at 2:30 pm

    wait i'm confused – so what exactly is the optimal dosage of vitamin d supplementation for adults? on a side note – is there also a know optimal dosage for toddlers?

  • Reply MushroomNr1 March 5, 2020 at 2:56 pm

    Is a weekly dose of vitamin D also seen as regular? The study doesn't seem to differentiate between daily and weekly but I might be mistaken.

  • Reply Joseph Stephen March 5, 2020 at 3:07 pm

    I think 12 hours working under sun it's enough VD against cov19 because I do every day 😂

  • Reply Andrew Zak March 5, 2020 at 3:19 pm

    Appreciate the great presentation of the studies✨

  • Reply John Becich March 5, 2020 at 3:24 pm

    By this reasoning, "roofers" ought to fare better than "office workers" or "miners." Roofers get lots of fresh air, and sunshine. I live in SoCal and have a garden plot; I get heavily sun-tanned in the summer but I think I'll go over there, pull the copious weed growth… with my shirt off!
    Thank you for this tip.
    BTW, I was found to be slightly VitD deficient, by blood test taken 4 years ago at the winter solstice. I will test again, and react thoughtfully. I'm an engineer, not a cowboy.
    Hey, those cowboys will bury me!

  • Reply Maxine F March 5, 2020 at 3:31 pm

    Been taking vitamin D for over a year now just for good health. But will go back and add vitamin C again.

  • Reply Sun Dog March 5, 2020 at 3:31 pm

    READ AND UNDERSTAND THE STUDIES BEFORE YOU CRAM VITAMIN D INTO YOUR SYSTEM!!! If you have low levels of vitamin D in your body, you may be at risk. That is when supplementation may help. (Notice, in that case, small daily doses are recommended over big ones.) If you have high levels of Vitamin D in your system, you will be at higher risk of cancers and other diseases. If you don't know, see your doctor and get a blood test. If supplementation of Vitamin D is recommended, then follow your doctor's instructions. If you have recommended target levels of Vitamin D in your system, supplementation will not help you and may put you at risk. Please, be smart and be healthy.

  • Reply Michael Sabedra March 5, 2020 at 3:49 pm

    🤜🏽🤛🏾 fist bump only to save humanity

  • Reply Randy Bruno March 5, 2020 at 3:51 pm

    Amazing stats! Thank you !

  • Reply James Smith March 5, 2020 at 3:51 pm

    If you get D3 try to get the liquid form, it's way better than pills.

  • Reply wave haven March 5, 2020 at 3:52 pm

    People coughing in the open air isnt ok anymore… A open bad cough is a cloud of microbeasts.
    Soon the N.C.V. will be accepted like the common flu that kills man thousands.
    Thanks Dr. for the good visits.

  • Reply Antônio Cruz March 5, 2020 at 3:53 pm

    Thank you, Dr. Seheult. Perhaps you may wish to investigate the use of vitamin C to help treat this virus. I read about it taken orally (in water), inalled (sodium ascorbate water), and in liposomal form. I am just an user of vitamin D3 and C, not related to any commerce.

  • Reply Paula Whyte March 5, 2020 at 4:02 pm

    I haven't gotten the flu, for almost 20 years now, even when everyone in my family gets the flu. I have been using a homemade remedy that I take sometimes 2 per month. My siblings wont take it because of the taste. Doctors told me that they wished they have a strong immune system, like mine.

  • Reply rafiki315 March 5, 2020 at 4:25 pm

    What dose should toddlers, babies and kids take?

  • Reply M Lo March 5, 2020 at 4:38 pm

    Hi please I need some advice from you I have low white blood cell you think I need to more carefully please waiting for your response thank you

  • Reply The Death Twitch March 5, 2020 at 4:38 pm

    I hope i get it and die cause i got nothing to live for.

  • Reply Ante A March 5, 2020 at 4:52 pm

    Very strange that a low-dose of vitamin D would be better than adequate dose! 20 ug will not elevate Vitamin D blood status. There is something fishy here!! Was the 50ug dose taken weekly? Did they really calculate vitamin D per day??

  • Reply Jason C March 5, 2020 at 4:59 pm

    I have also been hearing some initial studies that suggest that sunlight and higher heat helps to degrade this virus out in the open, decreasing the time it persists in the environment to be spread. Hopefully these studies are correct but unfortunately if this takes a strong foothold in the southern hemisphere which will be transitioning over the Fall and Winter, it can then become seasonal and return back and forth just like the common flu.

  • Reply Heather Sutton March 5, 2020 at 5:05 pm

    So we need to get vitamin D ? Sweet !
    🌴 Bahamas here I come ! Maybe, I can get a prescription for it !

  • Reply esti cami March 5, 2020 at 5:07 pm

    Ehm in Switzerland there are 58 cases and 1 death but whatever bruh

  • Reply AirRico March 5, 2020 at 5:18 pm

    Could breathing an atomized solution of chlorine dioxide CLO2 be used as a treatment for patients with CoVid19?
    In the hospital it could be added to the O2 given to the patients by adding it to the inline moisturizer.

  • Reply TomaCukor March 5, 2020 at 5:21 pm

    What is a small supplement? 10 or 20ugram?

  • Reply Mike Foster March 5, 2020 at 5:22 pm

    Stop with the insanity. Over 32,000,000 have contracted and over 18,000 have died from the flu in US this winter. Let me know when 10,000,000 have contracted or 10,000 have died from Covid-19 and I’ll start paying attention again.

  • Reply tata gata March 5, 2020 at 5:23 pm

    great work, thank you. I hope vitamin d is not made in china

  • Reply Elizabeth B March 5, 2020 at 5:28 pm

    Can you differentiate between a small daily dose of D and a Multivitamin containing D? In other words, is the Vit D contained in a standard Multivitamin sufficient for the D quantity indicated here? Thanks!

  • Reply 9 year old epic gamer soldier March 5, 2020 at 5:28 pm

    This is without a doubt the best place to stay up to date with coronavirus. And on the plus side this is also very informative and i'm actually learning something. So happy that this channel blew up. At least something good came with this.

  • Reply Tucsoncoyote 2019 March 5, 2020 at 5:29 pm

    So, drink more milk? If that's the case, get me a case of milk and I'll drink it..

  • Reply D.E.B. B March 5, 2020 at 5:38 pm

    Great excuse to have two big chocolate milkshakes every day.

  • Reply Latitude North March 5, 2020 at 5:41 pm

    Ironically 100 years post the 1919 inFluenza epidemic, WeThePple have f0rg0tten most real hi$t0ry! Another certainty is that so-called aUth0ritie$ are being "less than candid" or weeks behind in reporting true fActs. As of 02/22 mAny states had NOT done any testing, and therefore only reported acute cases while a-symptomatic shedding was, or is going on eVerywHere UN_hinDeRED!

  • Reply Heloise Armes March 5, 2020 at 5:43 pm

    I've been taking 50 UG (or 2,000 UI) daily now forever – never had a chest infection since I've been taking vitamin D daily (approx. 15 years). I've been giving my kids 25 UG; should I increase their intake also? They are both over 100 lbs and over the age of 10. Thanks!!

  • Reply Karen Shaw March 5, 2020 at 5:44 pm

    Aren't viruses PH sensitive? They supposedly cannot thrive in an alkaline environment. (I am drinking 1/2 teas. baking soda in H20 per day. Plan to get test strips.)

  • Reply Gregory Rogers March 5, 2020 at 5:46 pm

    Im scared. Ooooooooo.

  • Reply Latitude North March 5, 2020 at 5:46 pm

    Doesn't the epidemiology [curve] show UN_canny similarities w the 1919 InFluenza epidemic… a seeming Decline, and 'comeback', refUsalby aUth0rities to use the dreaded "P'word, etc.

  • Reply Fuckya Lookin at March 5, 2020 at 5:54 pm

    Love the videos but one piece of constructive criticism: lose the intro (“med cram DOT COM”). It’s just so cheesy. But I love the content.

  • Reply Scotty Lowry March 5, 2020 at 6:07 pm


  • Reply Z March 5, 2020 at 6:07 pm

    Vitamin D is fat soluble. For how long should a daily dosage be taken before scheduling a break from taking it? Take it for 5 days, break 1-2 days, resume another 5 days? Or is the suggested amount so small that there's no need to take a break from it?

  • Reply Anonymous Hobbit March 5, 2020 at 6:10 pm

    south africa had its first confirmed case annouced this morning

  • Reply Harry Fire March 5, 2020 at 6:21 pm

    How many people are walking around right now with a virus and we don't even know it? Apparently the CDC hasn't come up with testing kits and the ones they have now we don't even know if they work? No wonder Trump reduced their budget

  • Reply hmm9210 March 5, 2020 at 6:24 pm

    Nobody can give the cost of what the coronavirus test costs and there are no kits at the hospital or clinics.

  • Reply Maui Gal March 5, 2020 at 6:38 pm

    Any advice re using full spectrum light? Instead of or in addition to.

  • Reply moon flower March 5, 2020 at 6:38 pm

    Vitamin D is so helpful for depression

  • Reply dragonraide March 5, 2020 at 6:52 pm

    Me : "In the pig we eat everything"

    China : hold my Coronavirus!

  • Reply Khalid Huwaishel March 5, 2020 at 7:06 pm

    Why type of vit D!?

  • Reply Khalid Huwaishel March 5, 2020 at 7:07 pm

    Why type of vit D!?

  • Reply Leenesh G March 5, 2020 at 7:21 pm

    Spend time in the Sun

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