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Charles Brenner, PhD discusses Nicotinamide Riboside

August 19, 2019


  • Reply Don S November 7, 2016 at 1:27 am

    Is it best to buy it from the Elysium website or is the Amazon brand ok ?

  • Reply Nomen Nominandum November 16, 2016 at 12:56 pm

    Very profound information. Thanks for sharing.

  • Reply Jared Lee November 28, 2016 at 6:12 am

    At 12:46 when Dr. Brenner talks about blood NAD being up 2.7x after taking 1g of NR, is that measured in a human or is that 1g in a mouse model?

  • Reply Calabaza December 3, 2016 at 3:34 pm

    is NR related to D-Ribose? (riboside)

  • Reply clinton logan February 7, 2017 at 4:14 am


  • Reply ₡∆££ ¥∆₥A March 31, 2017 at 1:38 am

    the way charles talks is slightly unbearable – anyone know when those cancer trials will come to an end with results??

  • Reply Rhyothemis princeps March 31, 2017 at 8:14 pm

    Does it help with hair loss?

  • Reply Green Deane March 31, 2017 at 10:32 pm

    Does it interfere with exercise?

  • Reply Rupert Blitherington-Smythe May 13, 2017 at 1:01 am

    snake oil.

  • Reply Charles Darwin July 13, 2017 at 1:57 am

    so why dont you look younger?

  • Reply TRUTH&REALITY July 28, 2017 at 1:36 pm

    For someone who has a very active lifestyle. Does it increase energy levels?

  • Reply masonryjoe August 13, 2017 at 3:27 pm

    I take 375 mg twice a day.I thought there was a paper regarding human studies that said 600 to 800 was the rang that they noticed best results. Should I knock it down to 500 mg a day so I'm not wasting it ?

  • Reply Ancap Immortalist August 15, 2017 at 10:55 pm

    @ 32:00 it sounds like he is saying that high dose Niacin is has the opposite effect to what is intended. I currently take between 250mg and 750mg of Niacin a day. What is a "High Dose" as mentioned?
    Thanks for any help on this

  • Reply Day Brown September 8, 2017 at 9:08 pm

    I'm one of the 20 million post polio syndrome (PPS) survivors. Given the progression, I dont have time for well run double blind placebo trials. I usually tk 1000mg of NR daily, which I've been running low on, and my motor neurons are telling me about it. Fortunately, FED-X came by an hour ago, and now I get to see how much I can recover.

    Note: whereas conventional studies run for months or years. But give something to a PPS subject, and you get an answer on what your product does in days or weeks. PPS is just like normal aging, but several times faster. I am also more motivated to follow a regimen cause I could end up, in a year or two, totally paralyzed on a ventilator with a tube up my nose in Hospice; for years cause PPS does not damage the rest of the major organs. "The English Patient comes to mind.

    Besides NR, I also take Omega 3, DHEA, Resveratrol, trans-Pterostilbene, DHEA, COQ10, Prostate herbs, and Ginko. Is there anything else I should try? Dr. Brenner mite prefer I try NR alone to know what it does, but being low on it could be blamed on how woozy I've been today. The next test is whether NR merely stops the functional decline, or restores me to asymptomatic PPS. I can see how a study would want to look at just one thing at a time; but in the real world, us old folks are always popping pills. He mite like to know if NR plays well with others.

    Oh- forgot Buckyballs; in Olive oil. been a couple days I've been outta that also. The C60 sphere is pretty inert, you could get a lot of them eating charcoal, so I dont think there's a fatal overdose level. Senile cells. like other old folks, are messy. The immune system is spozed to come by to clean up, but it dont work like it usta either. But Buckyballs, when they get inside a cell, attach to the free radicals like dog ticks, and now the immune system sees, and hauls it off.

  • Reply Letta Mego September 10, 2017 at 1:49 am

    I take SAMe, folate, B7, B12.  These methylate.  Nicotinomine ribose demethylates.   So, can I take the two together or will they just cancel each other out?

  • Reply Quantum Chang September 10, 2017 at 10:28 am

    So Charles Brenner said that the mice were fed a gram of NR in order to get a 2.7 fold increase in NAD+ after 8 hours of oral ingestion. But they're selling capsules to people at a weight of 0.125 gram of NR each; and most people according to him typically takes 0.25 gram of NR daily. This dosage is half of what they gave the mice, and yet the human body is roughly 370 times heavier than the body of a mouse. This means the people that consumes these NR products out there will never see any rise at all in their NAD+. So is it a waste of money to by these expensive NR supplement that does nothing?

  • Reply Quantum Chang September 13, 2017 at 3:02 pm

    Intracellular NAD+ can be increased by inhibiting CD38 which is a NAD+ase by the use of apigenin and/or quercetin. Both have been found to inhibit CD38 and decrease acetylation of proteins and increase cellular NAD+ and sirtuin activity.

  • Reply Eric Mallet October 10, 2017 at 10:01 am

    I've tried NR for several months and I was very pleased for the extra energy it gives but I'd like to know why scientists say that a supplement of NADH has no effect but actually, it is not true. A supplement of 5 mg of NADH gave me more strength after 2 weeks. So, where is the difference in terms of cellular metabolism?

  • Reply chief da chief November 22, 2017 at 11:43 am

    Everyone reviewing nad+ just sounds like u, tiered, slow, speech full of pauses n still feels they are energetic….. strange….

  • Reply NAD Treatment Center November 30, 2017 at 3:58 am

    Great stuff from a brilliant man. We prescribe a lot of this in our clinic. For higher doses, we focus on prescribing Intravenous NAD. Patients show phenomenal results. If you are a doctor, please attend our, where Charles Brenner is a key speaker. — —

  • Reply Julia Myrna December 14, 2017 at 6:32 pm

    Hello. What dosage would you recommend to improve fertility? Thank you so much

  • Reply Mr Kayhan January 15, 2018 at 2:17 pm

    What a show, they sound intelligent because they use difficult words but basically they're saying crap.

  • Reply Huxxy February 1, 2018 at 1:37 am

    The interesting thing is that neither of these 2 guys look like the picture of health, OR the picture of youth. If this supplement works at all, one would expect improvements in biomarkers associated with ageing that could be measured, but also an associated improvement in the appearance of skin, hair, eyes, visual obesity…one would think all these things would visually improve along for the ride. Certainly with these 2 guys, it doesn't seem so. Well, perhaps they would both look worse if they weren't taking it, but that in itself isn't particularly encouraging. In fact as I would go as far as to say they both look quite UNHEALTHY.

  • Reply George Fatherson February 5, 2018 at 1:23 pm

    That stuff prolonges maximum life span just to 0.01% of mice! Not to 100%.

  • Reply ctguitarguy April 1, 2018 at 3:00 am

    How much NR does Charles Brenner take per day? 500mg?

  • Reply Stan Wilson April 2, 2018 at 2:47 am

    You still look extremely old

  • Reply David Brown April 4, 2018 at 2:00 am

    After starting NR, my total cholesterol and LDL went from 150 and 89 respectively to 214 and 149. My ApoB 100 went from 66 to 105. Nothing else changed in my daily living. I think that there is something very problematic with this supplement. Would love any reasonable explanation for its effect on my lipids.

  • Reply Bay Native April 16, 2018 at 8:49 am

    Is NR good to take right aftr an ischemic stroke?

  • Reply Slab Seeker April 21, 2018 at 2:55 pm

    Boy this is pitiful

  • Reply Sev Lop April 28, 2018 at 4:01 pm

    Where's the Before and After photos? These two old guys give me doubt on the success of their product.

  • Reply Patrick Pierre, Jr. June 16, 2018 at 2:40 pm

    So does NR stop or slow cellular damage by improving cellular replication and improving the replication process? Or does NR reverse damage already done and prevent future damage?

    Does it do this in humans and not just yeast, mice, worms…?

    That's really the main questions. Have human studies been done yet? I know studies have show that supplemental NR increases NR in the body but there are no studies about NR improving aging in humans.

    Right now this entire NR movement is entirely based on speculation.

  • Reply gilbert singh June 30, 2018 at 1:49 am

    When My Wife Had Cancer She Had The Runs All The Time I Read That Niacin Can Stopped The Runs For My Wife & It Did !

  • Reply Nadeem Hussain July 5, 2018 at 2:37 pm

    Is it works for high suger patients

  • Reply Stephen Downarowicz August 31, 2018 at 5:46 am

    What about the depletion of Methyl Groups? Can have adverse physical health and psychological effects. Too much of any form of Niacin is risky if not modulated with Trimethylglysine.

  • Reply buzzin1975 September 2, 2018 at 4:37 am

    White people are full of shit and lies. They just want to pop pills instead of eating real food and doing real exercise. Walking on a fucking treadmill or doing fake yoga ain't exercise either. Instead of doing all this selfish shit, why not work wth NGOs on alleviating poverty and actually go out and help people around the world. That's real exercise, like walking in nature and lifting real shit.

  • Reply halfmoon26 September 7, 2018 at 1:42 pm

    he was promoting NR over anything else, that means something

  • Reply Aroused floppeke September 20, 2018 at 1:56 am

    I have a rare mitochondrial disease (huntington's disease). I am suffering with extremaly muscle pains. After studying NR I know it shows some good results in HD mouse models. I wanna try NR in a higher doses. I have absolutely nothing to lose. If it helps me a bit that would be great, if it doesn't I tried. Can someone please give me a good indication of what dose I have to try. Does I need some other vitamins or minerals to take it with. Please help

  • Reply Ed Soderlind October 30, 2018 at 1:09 am

    will it fix my thyroid flare ups?

  • Reply Kathy Lambert November 4, 2018 at 6:28 pm

    This made me really ill. Allergic to niacin maubr. Suggested daily amounts 13 to 20 mg… this has 250mg x2 daily. Had a horrible reaction to this stuff.
    Weak nauseous and dizzy.

  • Reply WIN WIN November 18, 2018 at 7:37 pm

    Hi, I am 47 and was diagnosed lupus about 6 years ago. Can I take the pills?

  • Reply Tom Provan November 29, 2018 at 6:00 am

    Does nad cause vasodilation?

  • Reply Don Grey November 29, 2018 at 5:39 pm

    A gram a day, what the hell, whom can afford that~? The HPN Niagen bottle of 250 mg pills says take two upon waking. That is 500mg, so why does he say 1000 mg. Then he says those taking only 250 mg a day with remarkable result, so why the 1000mg, seems risky to me.

  • Reply Annmarie b January 23, 2019 at 5:32 am

    Could you please respond to studies, like this one:

    which claim that NAD increases the metabolism, hence growth, of cancer calls?

  • Reply Brooks Reed February 1, 2019 at 11:18 pm

    OOOOOOOR you can just intermittent fast and your body will produce not NAC+ ???

  • Reply cardenas262002 February 6, 2019 at 2:05 am

    These 2 look old, those supplements are obviously not working…

  • Reply Roxane Marin February 8, 2019 at 9:58 pm

    Why are people being so insulting and toxic? …Poor creatures. Thank you for sharing your research!

  • Reply App Man February 10, 2019 at 4:10 am

    Just use 'NR'..

  • Reply John Hart February 10, 2019 at 1:05 pm

    I'm curious to know if the host of this podcast, who has been taking NR since 2014, has experienced any beneficial outcomes in his own overall health, i.e blood work, exercise, sleep cycles, etc.

  • Reply Tomas Av. February 11, 2019 at 9:34 pm

    PhD menas nothing why da fuck americans loves to put that shit? In my country cashiers in "wallmark" have Phd.
    Anyway i rather believe in David Sinclair then those guys.

  • Reply Brandon Vitello February 13, 2019 at 9:01 am

    I have discounted Niagen if you want message me

  • Reply david wolf February 19, 2019 at 3:06 pm

    I think you would get similar results if you supplemented vitamin B3 and D-aspartic acid but they would never tell you that because in comparison its dirt cheep.

  • Reply Radnally February 21, 2019 at 6:00 pm

    In a recent interview, Dr Sinclair said he takes NMN, reservatrol and metformin on a daily basis. But, the dose levels would be pretty expensive for most of us having to pay retail prices for these products.

  • Reply Lilly February 22, 2019 at 12:29 am

    Where can we buy this? Amazon?

  • Reply Tana J March 1, 2019 at 5:19 pm

    Does anyone have side effects? When I took 2 capsules of Tru Niagen, I got a lot of dreams for whole night. So I have to reduce to 1 capsule, then I sleep better, but still have dreams from time to time. ( I used to sleep very well.) I don't know if I just take one capsule is still worth it?

  • Reply James Corsey March 1, 2019 at 6:36 pm

    What if u take blood pressure meds could u still take this?

  • Reply J L March 12, 2019 at 9:05 pm

    Were we accumulating NAD+ in the first 3-4 decades of our life(or net absorbing through diet)?

    Then as we aged, there was some physiologic shift in middle age where we could no longer absorb/create enough through diet, true?

    So then taking daily 1 g of NAD+ precursor(which is not something that happens in nature) is to induce a youthful intracellular and mitochondrial physiology, correct?

  • Reply BioStuff415 March 20, 2019 at 12:15 pm

    Interesting… but very few of these scientist look fit and healthy.

  • Reply yosser hughes March 21, 2019 at 11:01 am

    is this the most expensive version. can i just buy niacin or nictionamide cheaper.?

  • Reply Swimbait1 March 23, 2019 at 10:07 pm

    Lost me when he went off on his financial interests

  • Reply Gerald's Videos March 24, 2019 at 5:50 pm

    Thanks again.

  • Reply Great Uploads March 25, 2019 at 1:28 pm

    Agreed. Brilliant video and thank you very much. I got myself some today and will most certainly try it out and see for myself. I have noticed a huge difference after about an hour of ingestion.

  • Reply Walkon 33 March 28, 2019 at 2:31 am

    AMPK activators with no food can enhance NAD+. EEGC, Ginseng, Willow Bark, Curcumin, Pomegranate Peel Powder, Olive Leaf, Cacao

  • Reply Rohan Peiris March 28, 2019 at 9:14 pm

    Start an ico for NAD drugs, invest in bringing the price down. Allow holders of token to trade in for discount on products. Is this better than The Age Pill … and why ?

  • Reply The1trashman April 2, 2019 at 2:10 pm

    I just got my first order Thank you

  • Reply Grinder !! April 13, 2019 at 2:04 pm

    Can u discuss the possible side effects of demethylation when consuming NR and the decrease in creative and strength! I would also like to compliment you on your excellent interview with asking all the right questions that we are all curious about such as when to take it and with how to take it etc. Great job!

  • Reply Grinder !! April 17, 2019 at 11:56 am

    So I had been taking NR but did not notice any increase in my workout performance. However now that I’m taking NMN, I immediately had experienced niacin flush the first time, and then my workouts had improved by 20% like pushups, sit-ups, and chin ups!! I never expected nor anticipated this. I was only taking this for the longevity aspect of the molecule. What an awesome benefit with increased performance in my workouts and excercise. 🔥🔥🔥

  • Reply Grom KamoG April 23, 2019 at 8:15 pm

    Is plain Nicotinamide (NAM) safe and/or useful to help in NAD production?

  • Reply Eye Witness May 5, 2019 at 4:05 pm

    I got very sick almost immediately after taking Tru Niagen NRC, just one pill, half of the recommended 2 pills per serving. I got muscle pain, nerve pain, dizziness and tiredness, like in a bad fever. This is a pure and potent poison for me. Am I that unique?

  • Reply Alan Young May 11, 2019 at 1:30 pm

    I have prostrate cancer. Not yet at the prognostic stage. I get mixed signals that NAD+ has a negative /positive effect on cancer cells. Any thoughts?

  • Reply Jack Spier Gukasyan May 21, 2019 at 12:41 am

    Can it be taken with antipsychotics like latuda ?

  • Reply ReNto Quando May 24, 2019 at 10:44 pm

    It makes me and my wife sick. After 3-4 days taking NR 250mg/day we were sick like a poisoned.
    Be careful people with this product

  • Reply Mochi Mochi May 31, 2019 at 4:38 am

    NMN was awful for my gym lifts then I got a severe ear infection. Never had that in my life prior to nmn.

  • Reply NAD Repletion May 31, 2019 at 8:02 pm

    Just for the record, I want to state I'm for "NAD Repletion" and do not represent one form of B3 over the other. There are several paths to the same goal, some having benefits unlike the other forms and many overlaps appear after B3 is metabolized into NAD and NAM is produced. It depends on which path the B3 takes to NAD that determines some of the outlying benefits. Niacin, for instance, can be helpful in the therapy of hyperlipidemia. No other B3 makes these claims. So read up, the benefits of the new forms of B3 come from giving B3 a head start in the cell's metabolism which gets B3 to NAD quicker.

    Always remember taking too much of any supplement can also lead to health issues, so read up and keep your dosages reasonable.

    JMHO, be well.

  • Reply Biohaxxter June 1, 2019 at 12:05 pm

    Wow so many people reporting they get sick from tru niagen.
    I am taking NADH from vairvital and and NMN.
    The worst side effects i would note is slight muscle twitching at times, besides that only noting benefits.
    Energy levels up, motivated, focused and very pleasant tingling sensation in the spine.

    I am very sensitive to supplements over all.
    Can't take creatine or GABA or 5HTP even , all those give me headaches and skin issues.
    Just thought i leave this here

  • Reply Edward Bogusz June 9, 2019 at 9:54 pm

    Aren't CoQ10 and Pqq part of the same pathway?

  • Reply Fact Checker June 19, 2019 at 2:06 am


  • Reply Cast Boldly July 8, 2019 at 1:48 am

    I think NMN works much better then NR, but both are great fun for some older people. I'm amazed at the energy it give me..

  • Reply S V July 15, 2019 at 7:06 am

    Way more speculation and questions than answers. I think this science is years away from actually nailing down and interpreting their observations.
    I also think many of things said today will be discovered to be opposite as now understood.
    This story has been played out multitudes of times with various drugs and supplements .
    The list would be too big put here.
    Science is nice but people want a pill now today this moment.
    You're outta luck and going to waste a lot of money finding this out.

  • Reply Jayson Hennessy July 20, 2019 at 5:33 am

    Is it my imagination or does everyone who takes NAD boosters speak and think slowly.

  • Reply The Broken July 26, 2019 at 4:35 pm

    I don’t trust any “research” that is solely funded by the company selling a very expensive and patented product.

  • Reply Marcelo Rivadeneira July 29, 2019 at 7:11 am

    I experienced side effects related to methylation with the 250 mg dose. I started taking TMG to counteract the problem and I stopped experiencing the negative side effects.

  • Reply Demetrius Boronio August 2, 2019 at 6:48 pm

    What happens if you stop after several months taking NR?

  • Reply mybestideas1 August 4, 2019 at 2:16 pm

    The dude is fat. Maybe he should first work on being healthy?

  • Reply 呀你可 August 7, 2019 at 11:45 am

    Sir anyone can answer nmn+resveratrol vs NR+pterostilbene ? Which is better?

  • Reply Jeff Wolfenson August 11, 2019 at 11:22 pm

    You can tell both these guys are overweight. Good luck living longer with some magic pill. Exercise including weight training and a better diet will serve them better.

  • Reply Marky Mark August 16, 2019 at 9:58 pm

    What's the FDA trials and is it FDA approved ????

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