Articles, Blog

A Cure for Ageing?: David Sinclair at TEDxSydney

August 13, 2019

Translator: David Hsu
Reviewer: Denise RQ I believe that we’re all only given
one precious life. For those of us who are
really lucky to be born, it’s a life to be embraced, a life to be used for good, and a life that’s worth
prolonging in good health. When we’re all very young, we assume that our parents,
and our grandparents, all our loved ones will be around forever; but then we learn that that’s not true. I clearly remember my daughter Madeleine – here she is –
when she was four years old. I was putting her to bed, and she said, “Daddy, will you always be
around to protect me?” Man, it almost brings a tear
to my eye right now: I think anyone who’s been a parent
knows how this feels. And I said to her
– I had to be honest – I said, “I’m sorry. One day, like everybody,
I will grow old, and I will die.” I watched her eyes well up,
and she gave me a really big hug. But then I told her
– I think what we all tell our children which is, “Just don’t think about it,” and so she did. (Laughter) But here’s my big idea:
I think we’ve all done this in our lives, we all try to forget about this truth. Ironically, I believe
this is preventing us from realizing the lives
we could actually live. My grandmother Vera, she’s an amazing lady: she saved lives in World War II; she escaped persecution from Hungary
and fled to Australia; she had a wonderful sense
of humor, a love of life; and she spent a lot of time raising me; and she never wanted me
to call her grandma – only Vera – because she hated
the idea of growing old. But since then, I’ve watched her grow old. She has watched herself grow old too,
and she used to apologize to me for it. A few months ago, I heard that she fell over in her apartment,
and she broke the top of her femur. She went straight to hospital. They operated on her. Her heart stopped in the operation. I arrived in Sydney with my son Ben,
five years old, to say goodbye to her. She was there, just a shell
of the woman she once was. She had a feeding tube
coming out her nose. She barely knew who anybody was. And I thought, “This thing we call aging –
why aren’t we up in arms about it?” (Laughter) And this once vibrant woman,
reduced to this; it’s incredible. This is just my story, but this is being played out
every day in everybody’s family. It’s certainly not an isolated case. In fact, I don’t want to be a downer, but this, or something like it
is going to happen to all our loved ones, including all of us. That’s actually the best case scenario. So why aren’t we doing more about it? I think we all know
that aging’s important. For example, the World Health Organization
recently put out a report, a 32-page report saying that aging is one of the biggest
problems of our generation. Unless we do something to keep
the elderly healthy and productive, the cost is going to crush
national infrastructures. Our way of life, our economies
are going to fall. This is what the governments are saying. But what you may not realize is a fraction of just 1% of medical research is devoted to understanding why we age, and even less is devoted
to trying to do something about it. And this, to me, is a major puzzle. What I think is going on is
that we just don’t like to think about it. It’s really quite weird. I noticed many of you chuckled
when I was introduced. I think we’re just ingrained
to really not want to talk about it. We feel uncomfortable, embarrassed talking about extending lifespan
and delaying aging. For many people, it’s even sacrilegious. I once debated the bioethics adviser to
President George W Bush on national radio. His point to the audience, and to me,
was aging is natural. It’s part of the way of life. In fact, it makes life worth living. What a load of bull. (Laughter) Alzheimer’s, heart disease, cancer –
these are natural; and we do everything we can
to prevent and slow these diseases down. Ninety-nine percent of medical research is devoted to trying
to slow down these diseases, which actually, only a fraction
of us actually get; whereas aging,
if we’re lucky, affects all of us. So you might ask, “Why don’t we
just continue what we’re doing? Why don’t we just study
individual diseases?” That’s what we’ve always done.
It seems pretty good. But what you may not know is that the rate of aging is actually decreasing. What I mean by that is that we’ve developed many medicines
that actually can treat part of our body, say our hearts – we’re very good
at keeping our hearts healthy – but our brains still age. So we have ended up with – and just to use
my grandmother as an example – a nation of elderly whose hearts
are working well for example, but their brains
are no longer functioning. And this is a major problem
for a healthcare system. It’s extremely, extremely expensive. What we need are medicines that will keep all of our body parts
working at the same time. If we just fix one part of our body, the problem is some other part
will break down: we are just switching out diseases. I don’t think this is
the right way to go about it. If you look at this graph actually,
this really brings it home. We are always taught that our medicines are making us
healthier for longer. That’s not true. Look at this graph. The amount of time
that we are spending in good health is actually decreasing
in terms of percentage. No wonder healthcare costs are going up. What we need to do, of course,
is to keep us healthier for longer. So, I am not talking about
living for 500 years. I see that sometimes quoted in the press. But what I am talking about is an ability for us to live into our 90s
and our 100s in a healthy way and not like my grandmother who suffers. And many of us will go through this unless we do something
about the root cause of aging. I would argue it is
the greatest problem of our time. Well, let me tell you about the work
that I’ve been doing, a little bit, about how I think we can get
at the root cause of aging. So when I was in my 20s,
I earned a PhD in Sydney, and I headed off to Boston
to a place called MIT to understand why yeast cells, little budding yeast that we use
to make bread and beer, why they grow old – because, I figured, if we couldn’t figure
this out for a yeast cell, we had no hope of understanding
why we grow old. Fortunately, I did. And even though there were critics
of this approach, the critics were even Nobel Prize
winners who told me, “This is not the way to go about aging.
Yeast cells don’t get Grey hair. They don’t get heart disease.
They don’t get cancer. But I ignored them, fortunately. I was quite naive, luckily. And in the next few years,
what we discovered as a group was that yeast cells do,
in fact, grow old. and one of the reasons is that their genes start
to switch on as they get older. So what I mean by that is that– Every cell has a set number of genes;
we all know that. In every one of your cells:
the same number of genes, but they aren’t all switched on
at the same time. They need to be kept on and off and tell what type of cell is in the liver
and what type of cell is in the brain. What we found was these yeast cells
as they got older, after about a week, all the genes started
to come on, and they died. Now we could find genes that could actually slow
that process down. We could find genes that could switch off
those rogue genes and silence them. This led to a discovery
of a longevity gene called Sir2. Sir2 stands for
Silent Information Regulator 2. So in 1999, we started a new lab
at Harvard Medical School. I was 29 and figured
I could change the world. It was really exciting. We soon discovered that there are seven
of these longevity genes in our bodies. We call these the sirtuins. So the sirtuins have risen
to scientific prominence. There’re thousands of papers on these now. What we’ve learned is that they seem to protect
our body against diseases of aging. For example, If you put
extra copies of these genes into yeast, little nematode worms,
flies, and mice – they do a lot better. In fact, in most cases,
they live longer in a healthy state. So what we need to do
is to figure out ways to tweak these genes,
to make them more active. And, in that way,
we might be able to delay all the diseases we get as we get older, and, possibly, even reverse aging. Let me explain
what the sirtuins do in our body. I have been very fortunate that the TEDx people have helped me
make some videos here. There’s a new idea about aging: and that is that, as we get older, genes are switched on and off
in the wrong way. So when we are young,
there’s a beautiful symphony playing; but as we get older, the instruments, the orchestra starts to play willy-nilly
and screws things up. If we zoom into the cell,
you’ll see a chromosome. If we stretch out the chromosome, that’s the DNA
all twirled up, there in Grey. The pink blobs are proteins
called histones that the DNA is packaged in. Red means the gene is off. The problem during aging is that chemicals come in
and stick to the histones, and turn the genes on, so that’s what the green lights mean. This gene that should be off
in the brain of my grandmother is now coming on, and that’s a terrible thing. If this gene happened to be a gene
that told the liver to be a liver cell, and now it’s on in the brain, you can imagine the problem. And that’s what we think may be
a large part of what happens during aging. This leads to a really
important possibility. We used to think that mutations,
these irreversible changes to our DNA, are what cause aging; but, in fact, if it is this
– what we call an Epigenetic change – that’s reversible. So let me show you how we can reverse it. These sirtuins actually make proteins
that I’m going to show a cartoon of. It’s going to look like a Pac-Man. What the sirtuins proteins
do in our bodies is that they clip off
these chemical groups. And now the gene that was on
in the old person – in green – goes off again. And that’s what the sirtuins are doing
in our bodies right now. They’re stimulated naturally
when we don’t eat and when we exercise. And If we eat a large hamburger,
we shut them down again. This is not good. So what we wanted to do
was to find a way to turn this system on, to find a molecule
that could be taken in a little pill and turn on these sirtuin enzymes, and, thereby, we could clip off
these chemical groups, keep these diseases of aging at bay
and keep the whole body healthy. We might even one day, in theory,
reverse aspects of aging. As I said, I was in Boston and things
were looking really interesting. I started a company
that was based on the discovery that there were molecules
that could activate these enzymes. The one that we found ten years ago
which got a lot of media attention, was from red wine. It’s called resveratrol. And, don’t ask me to say that again –
it’s a hard word, resveratrol. And so resveratrol (Laughter) as you’ve probably heard, is in red wine. Now, the problem with that is that you’d need to drink
about 100 glasses of red wine a day. (Laughter) No, I don’t recommend that. (Laughter) Don’t do that. (Laughter) But what we clearly needed
was a drug that would do this. Something that’s more effective,
more potent than resveratrol. This company raised a lot of money, and they set to find molecules
that were even better than resveratrol. They found ones that were 100 times
more potent than the red wine molecule. They put them into animals. And these animals – I’m talking
about mice – were much healthier. They didn’t get heart disease. They were protected against Alzheimer’s.
They were protected against cancer. It was extremely exciting. They even started human trials,
and the molecules appeared safe. And there were already hints,
just little hints, that actually these molecules were working
the same way as resveratrol was working to prevent these diseases of aging. So at that point, everything looked great. I thought, “The world is going to be
different in my lifetime. We don’t have to worry.
This is going to all work out.” And then the bottom fell out. What happened was, a few years ago, the world’s largest pharmaceutical company
put out a scientific paper that said that all of this science
was wrong, dead wrong – that resveratrol did not work
on these proteins. In fact, another group said
sirtuins have nothing to do with aging. It was a really
depressing time of my life. I had emails from top scientists
sending me condolences. The clinical trials were put on hold. I thought I’d let my lab down.
I thought I’d let Australia down. I thought I’d let the whole world down. And there were days where I really wanted
just to quit being a scientist. But the good news was, the silver lining, was that it forced us in the lab
to go back and really understand how did resveratrol and these other
synthetic drugs actually work. So I pulled together a group of scientists
– there were about 30 of us – and set to work
to understand what was true. And what we’ve discovered is resveratrol really does bind
to that Pac-Man, sticks on the back of it,
and makes it chomp faster. That’s how they all work.
We were surprised. We didn’t realize resveratrol and these drugs all work
the same way, but they do. It was amazing. So the clinical trials
have started up again, and I’m hopeful that one day
– hopefully, not in a too distant future – there will be medicines
that we can take, say a little pill – I’ve got an example
of what it might look like – we might take one of these with breakfast, and that could ward off the diseases
of aging until much later and keep us healthier and functioning. I really look forward to a day
when this happens, and when it does, I believe we’re going
to look back at today, like we do people from a 100 years ago when people would die
from an infected splinter, which in those days, as you might recall,
was perfectly natural. I’m not only going to believe we have
a right to use this new technology to help ourselves and our loved ones; I believe we have a duty,
a financial and an ethical one. And if you don’t believe me,
just ask any four-year-old. (Laughter) Thank you very much. (Applause)


  • Reply Gold Hunter September 20, 2016 at 3:58 am

    IF the Powers That Be confiscate zero point energy patents under the claim of national security, I'm not sure they would be happy about us Unwashed Masses living for ever. Yet – I've been taking Niagen for a month an am below 200lbs for the 1st time in 25 years. Hope springs eternal.

  • Reply Vasto Lorde September 20, 2016 at 9:56 pm

    I hope they develop this fast enough before i die… i never want to die.

  • Reply R.B. September 27, 2016 at 1:26 am

    This doesn't make sense in principle. We don't only die because our genes start expressing inappropriately.

    Does this guy subscribe to Aubrey de Grey's way of thinking? I.e. that various forms of damage accumulate in the body as a natural side effect of being alive, and that over times these just accumulate to levels that get in the way of various necessary functions, until the levy breaks and something stops functioning, which kills the whole body.

    Because as far as I can see that's the only explanation of ageing that has ever made sense. The idea is beautifully simple, although in detail it is of course very complicated.

    So I like that this guy is raising attention to this most worthy of causes, but I hope he doesn't spend his life chasing down molecules that extend the lives of short-lived animals.

    I mean, is the goal to live to 90 with the body of a twenty-five year old, but then age and die inevitably, or is the goal to have the body of a twenty-five year old indefinitely? Surely the latter, if anyone wants to die, let them choose, don't have it be forced on everyone.

  • Reply Damjan Lisjak October 22, 2016 at 10:00 am

    This is probably the greatest man of modern era

  • Reply Gianfranco Fronzi October 22, 2016 at 10:58 am

    Why did red wine come under your view ?
    Leading to resveratrol ?
    There was time-tested proof of red wine having beneficial effects on longevity , I assume ?
    Then why do you go on to say you would need an enormous amount ?
    When three glasses a day work better than the drug ?
    What you are looking for isn't a drug , it's a way of thought .

  • Reply KitCox November 8, 2016 at 8:07 pm

    All we have to do to become immortal is do what yeast, a particular jelly fish and cancer cells do. These are ALL immortal and never die from "aging" in spite of what Sinclair says. He's basically full of poppycock. The only things humans have to do to become immortal is do what yeast and cancer cells do: Repair the Telomeres after cell division. On the ends of ALL chromosomes are stretches of DNA called telomeres. These protect the ends of the chromosome from unraveling, like the aglets on the ends of shoelaces. The problem is that when a cell divides all the chromosomes are duplicated and then split in to two identical strands. During the splitting a small section of the telomere is snipped off. When the telomere is all gone, after about 10-20 divisions, the DNA starts to become seriously damaged, causing the cell to go into cell death. This does NOT happen to cancer cells. At the time of cell division the cancer DNA has a gene that creates an enzyme called telomerase. The cancer telomerase repairs the chromosome end, never allowing the cancer cell to die an old age death and continue to divide for ever.

    End of discussion. The fact that this Sinclair didn't mention all this but instead produces the names of four different companies he owns selling crap like resveratrol etc. proves he's a fraud.

    Comments please.

  • Reply Leong Munglan Gwendoline November 11, 2016 at 4:06 pm

    When we get clogged up, our colons that is, our blood reproduce DNA with mistakes. Gone off wack. More piiles up until they get dysfunnctional (those meat eaters) Cos the diet is too heavy and u digestible So ageging starts. dysfunctionality….

  • Reply nitin garg November 23, 2016 at 9:03 pm

    David Sinclair Sir: we are not given only 1 life. We are reborn life after life so no need to do anything abt ageing of physical body.

  • Reply Tina K.P. December 3, 2016 at 9:54 am

    But if your body repairs the damage by itself until "you eat a hamburger" (or probably anything else) why then even waste time on developing a pill that does the same while you eat. Just don't eat for longer periods of time as you age.

  • Reply Ecco Sabanovic December 16, 2016 at 9:54 am

    .. so, getting old is a disease ?? ..

  • Reply Marina Radusin December 26, 2016 at 3:17 pm

    We are not ever free! We have a master to control us because we are too dumb to make it our own. We become free when we die! And thank GOD for that.

  • Reply idak12 January 8, 2017 at 2:39 am

    These scientists who think they are smarter than God or mother nature are truly evil. All they care about is getting rich. If we want to live longer and healthier and not get cancer, why don't they stop putting chemicals in our food and water.

  • Reply Call me Hater January 23, 2017 at 9:50 am

    I wonder who want to stuck in this fucked up dimension??? Die and explore another world:)

  • Reply Call me Hater January 23, 2017 at 9:50 am

    I wonder who want to stuck in this fucked up dimension??? Die and explore another world:)

  • Reply Hayley Northcutt January 28, 2017 at 3:36 am

    medation to look 30 years younger

  • Reply Maria Dacosta January 30, 2017 at 3:24 am

    Try Pregnenolone and focus on the wonderful hormones. We start to grow old when our hormones start to go down…

  • Reply Bob King February 12, 2017 at 3:09 pm

    get to the fucking point..

  • Reply TomP Home February 14, 2017 at 4:44 pm

    I can understand the vast amount of skepticism and conspiracy theory beliefs many people have about the pharma industry. Most lay people, myself included, know very little about what it is we have an opinion about this on. There is the scientific method in play here, along with proper experimentation, hypotheses, implementation, regulations…and on and on…

    This is NOT simple, nor are these issues easily explained by a simple – one size fits all approach. In my opinion, this whole controversy about the pharmacological industry conspiring to keep us all sick and on their drugs boils down to our own personal paradigm about life and people in general.

    If I believe that mankind is greedy and evil – conspiracies exist everywhere. In government, money and banking, medicine, education, terror attacks (911)…everywhere. If I think all men (and women) are self serving, evil, lying, money grubbing scumbags – then I whole heartedly agree that the entire medical industry is corrupt to the core and all they want to do is keep us (barely) alive so we can buy their concoctions en-masse so as to line their greedy pockets.

    Personally, I do not subscribe to this notion so I am forced to examine the medical industry more closely. Every single one of these so-called greedy lying bastards is a human being. Which means it can be argued that they all want to live as long as possible and in good health.

    Every single one of these human beings has a mother, father, child, brother, sister and or even pets that they would like to be around for ever….some maybe not as much as others – I mean there ARE bad people on the earth…I grant you this.

    However, the VAST majority of these people that are working on these medicines and treatments are trying to do good. Assuming this is true, would they be willing to work with or for a company that is so corrupt that it only cares about milking the general public dry? Don't you think this would not sit right with these people?

    I am growing weary of all these people who are so sure that the entire industry of medicine is corrupt in such a fashion. What I do know is when I hold others in judgement I a putting up a reflection of what I hold to be true inside of myself. I believe that people are basically good and want to do good.

    Yes there are unintended consequences associated with ALL actions. There are SOME bad actors in ALL industries. But to paint the entire pharma industry with such a broad brush is silly and counter productive. Specially without verified and vetted PROOF that such a situation actually exists.

    And I am NOT talking about some you tube video and or conspiracy theory type of web site. We live in a very complex world. A world that few of us can keep up with and understand – me included. It is good to be skeptical, but it is also foolish to blindly believe everything you hear or see online from someone who makes a living by spreading fear and loathing at every turn.

    I guess my point here is just this. We make real the things we desire AND fear most. I choose to focus on desire and positivity. After all – it is this totally corrupt and greedy industry that saved MY life from leukemia over a dozen years ago. My treatment ended when I went into full remission. Was the price of the medicine they gave me worth it?

    You bet it was – every damn penny of it!

  • Reply Tiago Carvalho March 4, 2017 at 5:46 pm

    ELIMINATE, FIRE, ICE, AND PAIN FROM THE BODY, and you stop aging. I created a therapy to achieve this. I used the therapy on my body, and I am getting the results.

  • Reply Larry 21603 March 11, 2017 at 5:07 pm

    If you cure anything the system will run you out of town. Old age is not appreciated until one gets there and they you can't do anything about it.

  • Reply Joshua Flow March 16, 2017 at 2:39 am


  • Reply Joshua Flow March 16, 2017 at 2:41 am

    Human trials I'm willing to try.

  • Reply Rozli Yusof March 22, 2017 at 6:13 pm

    what about HGH release?

  • Reply Jazzy7664 March 26, 2017 at 1:11 pm

    He reminds me of Sam Neill from jurassic park.

  • Reply Syth .Mog March 27, 2017 at 1:07 am

    That exiting statement was one of the most supercharged pathos ive ever felt… damn him single tear

  • Reply Sleepy Joe March 28, 2017 at 3:32 am

    I'm just going to put my head onto a robot body and live forever.

  • Reply Z4RQUON April 4, 2017 at 3:04 pm

    I would add this to the water supply

  • Reply HEΛRTS OF SPΛCE April 7, 2017 at 5:41 pm

    Why is "aging" misspelled in the title?!?! This is TED!! Come on guys!

  • Reply Timmy J April 10, 2017 at 11:21 pm

    An optimal diet is the only cure to aging, and I'd like to call it the ultimate inhibitor…not cure.

  • Reply Conrad Rideout April 18, 2017 at 6:04 pm

    How much would that pill cost? Great another company that will be looking to line pockets.

  • Reply K Reuter April 19, 2017 at 3:58 am

    Good luck! don't give up!!

  • Reply Michal Turlik April 22, 2017 at 8:14 pm

    Another American Bullshit, make audience, make money and try to purchase something working by paying talented work of poor people…that s the California Dream. The next show what it is going to be? Some Propaganda about a sensational shampoo that cures baldness, myopia, impotence, badness? Nope for the latest there is no cure…maybe by closing americans in America…the world should ask Trump to create a barrier around USA…who knows…

  • Reply François Morin April 25, 2017 at 2:57 am

    Two thumbs up! Sadly by the time those anti-aging medicines will be out on the market I will be about 65. We at least deserves to age healthy and beautiful. I should be among the first generation testing those cures if the pharmaceuticals push those researches. Thanks!

  • Reply solid9 April 25, 2017 at 9:38 am

    NAD+ I wish the clinical trial will be successful.

  • Reply leroy umland April 29, 2017 at 8:07 pm

    Pharma doesn't want lose on a cure for any thing that would cut into there money make Business

  • Reply Michael The Sociopath May 1, 2017 at 2:16 pm

    What really makes me laugh is how internet SJW vegans use pseudo links to show how we need to be vegans for a long lifespan. That's objectively false and probable to be so. Most old people who live past 100 years old eat meat.

  • Reply yhoff76 May 5, 2017 at 11:25 am

    Evolution has designed us to age and die. This process has proven to be beneficial for our species. A brazilian scientist has run this scenario in silico and the results were amazing. Having younger minds more keen to learn and not obstinate to adaptation because of their limited life experiences is what improves our species, not living longer.

  • Reply Sameer Pawar May 17, 2017 at 12:10 pm

    Only videos like these help me fight depression and suicidal thoughts. Merely birth does not mean having life. Life means having enough time on your youth to full fill all your wishes and responsibilities. Just the hope of having eternal youth and enough time keeps me alive and ready to face all the challenges my way. Having eternal youth and 100% Health would solve all problems and insecurities to humans.

  • Reply Hugh Gray May 20, 2017 at 5:26 am

    Nobody, Not one person has made it out alive. 100 is common now 110 a few 120 plus. forget it. The county would go broke paying the pension unless we keep increasing the retirement age.. I guess after 100 we would not even be any good as. dog food.

  • Reply Dan Floros May 23, 2017 at 7:59 am

    the ghost in the machine…childhood trauma untreated an unaware plays a significant effect… medicine looks the other way unfortunate $$$$

  • Reply Valery Chuprin June 5, 2017 at 1:49 am

    You can start rejuvenating the old body today. The human body has powerful regeneration mechanisms for this. If you rejuvenate your old body, you will not die of old age, you can live forever while the body is young. Read the FB Valery Chuprin

  • Reply Minoja Gerard June 9, 2017 at 8:25 pm

    I don't like this pill menthatlity…

  • Reply Fay Done June 10, 2017 at 10:31 am

    Yes because changing our Diet & Lifestyle is too much hassle… Just take this synthetic Pill !! ??

  • Reply KimsonJohn June 11, 2017 at 6:33 am

    You can activate those SIR-2 genes or "pacman" through exercise and fasting.

    pharmaceutical companies know it's more important to keep people sick or dependent on treatment than when we are healthy and with slowed down aging processes.

  • Reply Maria Lourdes Cleofe-Menor-Mendoza June 17, 2017 at 7:27 am

    He owns the company and does research at the same time. There seems to be no more state-funded general research anymore. Every scientific advance, instead of being released to increase the standards of living for everyone, will always be packaged up in pills that only the richest can afford. This new kind of social-darwinist selection is ethically questionable.

  • Reply Carousing Cockatiel June 18, 2017 at 4:14 am

    There is a lot of progress being done in the longevity-related fields of research, folks, thing are looking great. So far, only for mice and worms, sure, but there are a lot of things for humans to loook forward to as well. If you want to know more about it, as well as discuss the topic with knowledgable laymen and some actual scientists, come over the longevity discord:

  • Reply Crazy Duck June 18, 2017 at 2:24 pm

    i know i will live for ever,but unfortunately you all guys have to die…. 🙁

  • Reply Enrique Velez June 21, 2017 at 3:01 pm

    So did this pill ever got made at all?

  • Reply tamarensis June 21, 2017 at 3:40 pm

    The pharmaceutical company that gets the more efficient molecule to activate sirtuins is going to monopolize a great part of the market..the war is served.

  • Reply Some Guy June 24, 2017 at 10:57 am

    if people stop dying we can no longer make children for obvious reasons

  • Reply Angelicatoo June 28, 2017 at 1:57 pm

    how many 4 year olds ask questions like will you be around to protect me? ruins credibility.

  • Reply Ajit Apte July 1, 2017 at 2:56 pm


  • Reply Michael M July 3, 2017 at 4:06 am

    am I the only one thinking that that pill he had was actually the cure for ageing; cause he said pharmaceutical companies lat him down; but no such thing pharmaceutical companies don't want the Cure so I think he said that just to cover his end so then people won't come after him. I believe he already has it..

  • Reply gurlgenius11 July 3, 2017 at 10:36 pm

    It's spelled "a-g-I-n-g."

  • Reply Ira Schoenberger July 7, 2017 at 10:17 am

    This is >> a Swiss-made cream which is built to help reduce major signs of aging. It's presented on the Leading Edge Herbals web site, which is very simple and very easy to navigate. The website offers customers a comprehensive description of this product including the science behind the method and an informative FAQ area.

  • Reply Steven Marshall July 7, 2017 at 2:54 pm

    ever notice those who talk anti ageing looks old..

  • Reply Ryan Welsch July 8, 2017 at 4:37 am

    He is trying to reinvent the wheel and make it more complex. The method to undo aging has been known for decades. It is called regenerative detoxification. Humans are not smart enough to improve on nature. Every time they stick their hand in the cookie jar, something else breaks.

  • Reply Serenity Oasis Spa & Retreat July 9, 2017 at 7:49 am

    Very interesting… my parents both also escaped persecution in Hungary. My parents (Szucs & Riesz) stowed away on a Japanese ship headed through the Panama Canal Landing in Brazil. My name on my birth certificate is Vera Arlin. Excellent topic and presentation!

  • Reply Joyce Miller July 16, 2017 at 7:05 pm

    The idea that a pill will reverse aging is totally pathetic and deluded, motivated by greed and the idea people will be stupid enough to buy it.

  • Reply Juanita Val July 16, 2017 at 9:41 pm

    David is the obligation to the government to help people died with dignity then the people will be so comfortable to be old in number and happy inside as a person, congratulation the world need so many people like you to help the humanity, buildings cover with gold is going to be perpetual humans are just passing bye, therefore we should bee consider better life at the beginning and at the end.

  • Reply Sibtain Mumraiz July 21, 2017 at 6:29 pm

    Great Job!

  • Reply Lou Bob July 21, 2017 at 9:13 pm

    Americans could live longer and still be unhealthy. Amazing.

  • Reply Orlando July 22, 2017 at 7:47 am

    If aging can be explained by epigenetic then it's possible to reverse aging naturally and without red wine. According to epigenetic it's the perception of our environment that has a big impact on our health and of course longevity. Which means that our thoughts actually make us sick and old. What would happen if we would think only healthy and positive thoughts on a daily basis? Doing all that naturally comes from these healthy and positive thoughts? We have to learn to cure ourselves without pills because that's what our bodies were originally designed for.

  • Reply MrDoublehappy August 5, 2017 at 10:57 am

    I waited and waited for the title of the video but it didnt after 5 minutes so i switched him off … this is really annoying on youtube

  • Reply xtra1957 August 14, 2017 at 5:07 am

    … wouldn't it be unfortunate if this man died of old age …

  • Reply Geoff Boswell August 20, 2017 at 7:23 am

    Well said. All these aging deaths are horrible and no effort is put into solving the problem, only receiving symptoms. BUT This is a systemic problem in the modern medical industry. They are not interested in finding causes for any illnesses including aging/death. They concentrate all their money on treating symptoms and in supporting the industry. We need to educate people on healthy eating and maybe legislate to stop unhealthy food from being sold and we need a health industry that concentrates on finding the causes on illness and solving the causes, not just treating symptoms.

  • Reply Al Bourne August 21, 2017 at 12:08 am

    Lets hear from some 80 – 90 100 years old about anti aging

  • Reply ridetube66 August 23, 2017 at 10:45 am

    Big Pharma is one of the BIG human FARMERs. We are their domesticated livestock. The soulless criminals that run the world from the altar of their almighty god the "free" market see poor humans in this way.

  • Reply john miller August 24, 2017 at 3:22 am

    Sad David Sinclair. He's got Death Anxiety really bad. Check out Terror Management Theory or Ernest Becker's book Denial of Death.

  • Reply Joelleen Beangh September 13, 2017 at 11:21 am

    Hundred gleases of red whine a day with resviretrol will guarantee you ethernal youth. LOL

  • Reply Joelleen Beangh September 13, 2017 at 11:26 am

    Tell me the name of the other antyaging compounds this Doctor did not mention. I want to know, i am a biologist warking on reversing alz.

  • Reply GRANTFROM GOOLWA September 17, 2017 at 2:22 pm

    Where do I sign Up.

  • Reply santsuma September 19, 2017 at 7:13 pm

    "Perfection is achieved, not when there is nothing more to add, but when there is nothing left to take away." – (Antoine de Saint-Exupery).

    Apply this Saint-Exupéry sentence to eating and you will improve your health by taking away from your meals all the junk food, industrialized/processed food, contaminated, toxic "pseudo food" containing all the industrial chemicals added to food, etc, etc…

    The food industry works to make you like the food taste by adding all kinds of flavor enhancers, they also work hard to make you eat MORE (they make more profit when you eat more,that is a no brainer).

    Then comes the food industry "business partner", Big Pharma and make you addicted/dependent on pills to "manage" the diseases symptoms, not to cure…
    The best,simplest, cheapest way to being physically healthy is to eat LESS amount of food, eat organic only, less processed food and food that is the closest to mother nature.

    I have been awakening to these truths since teen age. At 68 now, my BMI= 23, muscles in place, very fit, eating mostly one meal a day, with plenty coming from my own natural/organic/veganic kitchen garden.

    "Natural garden" meaning I do not use any industrial materials in it (plastic, cardboard, etc.)
    "Organic garden" as I do not use any agrotoxic products (synthetic fertilizers, herbides, etc). And "veganic garden" as I do NOT use any any kind of animal manures to build up my garden soil quality.

  • Reply justmadeit2 September 20, 2017 at 5:34 am

    Ageing is something you think about more once you get over 35 or 40….I made something about it, if you want after this, give it a watch, just type in the following title,……Ageing You're getting older too

  • Reply No trap music Hip hop music channel September 26, 2017 at 6:15 pm

    How do we invest in this Company?

  • Reply dimethylhydantoin October 4, 2017 at 4:20 pm

    I wouldn't be surprised if the research that came out to discredit his team's findings was tailored to help keep people sick and dying at a good rate.

  • Reply hybrid green October 9, 2017 at 2:22 pm

    Considering existence of self degenerating organisms and ones that grow, but not die, aging is likely to be a malfunction that we most species acquired…or was programmed into our blueprint. It sucks that jobs offered are in tsa, phone call centers and cash registers. More people need to work on slowing down ageing instead of pointless jobs, partying and making more babies. Make less babies and put effort into making them healthy and smart. Otherwise grand kids of this generation will live 5 people in a single studio, eat yeast and have voodoo and snake oil for medicine…except for rich kids on the islands, who will also be screwed since the planet won't be a pretty place with o.k. climate any more. Can we prioritize at all?

  • Reply Positive Unity October 11, 2017 at 1:48 pm

    Conciousness will keep you young. Why can some spontaneously cure cancer?? What was the human capabilities of the past? Diet is important for the temple your brain also controls the body. Find spirituality!!

  • Reply Bruce Barrett October 15, 2017 at 2:50 pm

    niagen is his baby and evidently it was not ready to be born when this was filmed.

  • Reply Sploof Mcsterra October 31, 2017 at 4:05 am

    Just a few thousand dollars of investment could decide whether you are the last generation to age, or the first to stop aging.

  • Reply Emma w December 3, 2017 at 1:36 pm

    We need to be physically immortal so people etc who passed away are here spiritual potentially physically again and me u all not passed away we need to never ever die in first place. We need to physical immortal with no end literally we need to never die literally we need to be young age permanently. All illnesses need to stop permanently. People who do crimes need to stop permanent we world need to be literally infinite. All scary things need to stop….

  • Reply Bobby Garner December 17, 2017 at 1:35 am

    fastest way to stop aging. die.

  • Reply pieter cloete December 29, 2017 at 8:53 am

    This blog is about 6 years old and no new updating. Why??

  • Reply hend goname January 23, 2018 at 12:41 pm

    Hey theres a man born at 1988 that looks like he is 12 years old he is completely and absolutely normal looking you wouldn't think twice about him being a 12yo only he is not
    He is called mohammed farouq Google him
    I feel like he didn't get the attention he should have gotten

  • Reply DNA Diagnostics May 5, 2018 at 8:42 pm

    Bioethicists are generally a group of losers who hamper progress. Whenever there is some advancement in genetics, bioethicists will get in the way. If the US is to stay competitive, they need to fire bioethicists. Private firms will outcompete public institutions partly due to them not hiring people who impede their own progress unlike public institutions who will have a quota of liberal arts bioethicists.

  • Reply Bianca Beauty June 22, 2018 at 12:41 pm

    anti aging

  • Reply rikk sashquat June 27, 2018 at 10:11 pm

    tired of mainstream medicine pushing toxic chemicals and calling it treatment

  • Reply rikk sashquat June 27, 2018 at 10:13 pm

    where is the profit in curing a disease when there is a lot of money to be made by giving them chemicals for the rest of their lives

  • Reply Mark Rendy July 9, 2018 at 9:41 pm

    spending lots of time on YouTube causes ageing

  • Reply Riley Willcox August 21, 2018 at 4:40 am

    "We die, so that others can be born,
    We age, so that others can be young,
    The point of life is live,
    Love if you can
    Then pass it on"

  • Reply paul cheng September 14, 2018 at 12:52 am

    Should have a new update of the info

  • Reply Sun October 8, 2018 at 10:04 pm

    5 years later 🙂
    What substance(s) have been identified so far working the way D. Sinclair told us?

  • Reply heidi smith October 24, 2018 at 10:39 am

    What do you think of NDA?

  • Reply heidi smith October 24, 2018 at 10:44 am

    Could you spell theses drugs for me so I can do more research. Thank you.

  • Reply Mace October 31, 2018 at 2:02 pm

    The problem of aging is a physics problem. All damage to the body can be
    attributed to entropy. It may be possible to repair body systems using a
    mechanistic approach, but radiant youth will not be established that
    way. It may be that aging is 100% due to entropy, and that if that
    entropy was dealt with, the body would revert back to a youthful form.
    You have to notice the difference between a youthful body and mind and
    an aged body and mind. The amount of energy flow through the body is the
    crucial difference. Even the breakdown of the telomeres can be traced
    down to entropic influence. Korean and Japanese girls have lots of youth
    because their bodies have more energy flowing through them. Essay:

    Atoms are subject to rust, rot, and degeneration. However, if you
    constantly run an electric current through a piece of metal, the process
    of rusting will take much longer. Running energy through matter can
    achieve this same result for other substances too. Matter is a high
    entropy substance, but applying coherent energy to it can make a
    difference. In our bodies the condition of advancing entropy is
    temporarily offset by ingesting food, which provides energy to cells and
    reinforces their structure. Energy is also replenished by the sleep
    cycle, and by energy chakras that take energy from the sea of energy
    present in the world and also spiritual dimensions.
    Matter may not be as connected to vital energy fields, when compared to
    the human spirit. Matter's connection to energy fields may be weak and
    objects made of matter may be compartmentalized and mainly cut off, like
    separated, discrete islands. Pieces of matter have a propensity to rub
    against each other randomly in the environment (or external energy
    impacts the matter indirectly from various sources), causing destructive
    friction and descent into entropic disorder. Energy circulation and
    influx systems are combating this tendency in the body, but eventually
    they fail. The deterioration of the telomeres is an example of this, the
    telomeres eventually decay because of entropy's influence and failure
    of body energy systems. It seems that the body is not receiving enough
    energy as it gets older, which is really what causes the breakdown into
    entropy. The resulting disorder manifests as missing bits of telomere
    DNA code that pass into evaporation. When available energy in the body
    is at a low state, it is closer to entropy, and thus degeneration. What
    the body needs is a constant supply of energy in order to keep it
    intact. Energy must be running through all parts of the body, every cell
    and DNA strand, on a constant basis. This is not a simple task. The
    consciousness of the person must be adapted to permit this, or
    overstimulation of the mind will lead to madness. The amygdala, or
    pituitary gland, can receive energy from energy resources that extend
    beyond our Universe.
    When a coherent resonance state of energy in the body is reached, time
    will slow down for the person and even timeless reality can be
    experienced. Spontaneous teleportation and time travel avenues may open
    up for a body so enhanced. Entropy may reverse, and negatropy may ensue,
    which is the state of coherent, high energy resonance, accumulating
    energy flow, and interconnection. All energy converges at a high energy
    state, so when enough subtle energy is passing through the body normal
    parameters of physics will no longer apply. Stability will increase,
    rather than abate. The process is not without risk, as many phenomena
    will rapidly be encountered, but who said that living forever would be
    boring. Once the body is exposed to a high energy resonance reality it
    may explore various pockets of resonance, that ultimately comprise the
    energy continuum. In conclusion, energy and the connection to energy
    fields is the means to immortality. Our body, in its current state of
    matter, is subject to erosion. Circulation of energy through the body is
    thus necessary to delay the aging process. The energy has many safe
    sources, energy from food, sunlight, chi energy, kundalini, energized
    water, minerals. The answer to longevity will likely not come through a
    pill or therapy, but by enabling the body to receive enough life giving
    energy so it is made stable when high energy resonance is attained.
    Extreme longevity is somewhat the realm of the spiritual hero or science
    fiction adventurer, but it may be feasible.

    The implications of supreme longevity are radical. Understanding
    regenerative Physics is the means to discovering how longevity can be
    extended indefinitely. Consciousness and its connection to source energy
    completely circumvents entropy, reversing decomposition and maintaining
    stability. Deliberate commitment to focused, high energy resonance and
    interconnection to energy fields can lead to eternal life. Relying on
    virtually disconnected and detached matter will eventually lead to
    death. Energy does not have to always flow downhill, it can flow uphill
    into higher dimensions. The mind is the prime engine of this upwards
    action. Energy can flow both downhill and uphill, in a feedback circuit
    of interdependence and escalating dynamics. Once the body and mind are
    firmly plugged into the spiritual energy flow and are receiving copious
    energy, the accessible niches of experience are interminable.
    Opening and exposing the human physical body (or any other piece of
    matter) to a burgeoning stream of spiritual energy will cause the matter
    to act in manners that are not typical of its usual virtually sealed
    off condition. Exposure will strengthen and augment matter so treated.
    Interconnection is positively correlated with coherence, when
    interconnection is improved coherence increases. Harmony between
    interconnected entities is the synthesis.

  • Reply Goran Svraka January 9, 2019 at 4:18 pm

    explain…the pacmen are stimulated when we dont eat and when we exercise…so that means anorexic people live longer…or eat a bare mimumum? I dont eat as much as i should be and am skinny atm does that mean i will live longer?

  • Reply RawLu February 20, 2019 at 3:59 am

    I'd love to live forever to see as much of this incredible universe, as long as 'Everyone' can choose to live well as long as they choose? Not only the rich…

  • Reply mostafa hussein March 21, 2019 at 2:09 pm

    Sign me in to the cure please ..

  • Reply Ali Rafatjah May 1, 2019 at 7:01 pm

    It's been 6 years from the date that I write this. What ever happened? Does anybody know where is this drug? Any comments would be appreciated.

  • Reply Trampoline Viagra July 13, 2019 at 11:56 pm

    Is it just me, or does he actually look older here than he does on Joe Rogan?

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